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BioMed Research International
Volume 2016, Article ID 9027489, 9 pages
http://dx.doi.org/10.1155/2016/9027489
Research Article

Gamma-Ray Treatment of Echinococcus Protoscoleces prior to Implantation in Mice Reduces Echinococcosis

1Department of General Surgery, Ya’an People’s Hospital, Ya’an, China
2Hepatobiliary Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, China
3Ganzi State Hospital, Kangding, China

Received 2 February 2016; Revised 20 April 2016; Accepted 30 May 2016

Academic Editor: Anna K. Walduck

Copyright © 2016 Qing Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Echinococcosis is a serious parasitic disease caused by Echinococcus tapeworms. Protoscoleces are sometimes released during surgical treatment for hydatid cysts, causing the recurrence of echinococcosis. Protoscoleces may be susceptible to radiation therapy. In this study Echinococcus protoscoleces were cultured in vitro and then divided into four different γ-ray irradiation dose groups (10 Gy, 20 Gy, 40 Gy, and 80 Gy) and a blank group. The protoscoleces were then implanted into the abdominal cavity of mice. Four months later, we observed that the incidence and weight of cysts declined with the increase of irradiation dose. γ-ray irradiation can suppress the generation of Echinococcus originated from protoscolex, the reason of which is due to the damaging to the structure of Echinococcus. Irradiation may prevent echinococcosis recurrence after surgical removal of hydatid cysts.