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BioMed Research International
Volume 2016, Article ID 9060143, 5 pages
http://dx.doi.org/10.1155/2016/9060143
Review Article

Platelet Activation: The Mechanisms and Potential Biomarkers

1Department of Biochemistry, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea
2Department of Laboratory Medicine, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea

Received 27 March 2016; Accepted 26 May 2016

Academic Editor: Michele Cea

Copyright © 2016 Seong-Hoon Yun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this review, we discuss recent advances in the pathways of platelet activation and potential application of platelet activation biomarkers to diagnosis and prediction of disease states.