Research Article

Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study

Figure 3

The standardized uptake values (SUVs) of a bolus and a programmed infusion (PI) study on the same subject. (a) and (b) show arterial plasma SUV and occipital cortex SUV of a bolus study, respectively. From the bolus data, a PI scheme was designed. (c) shows the infusion scheme; the measured occipital cortex SUV; the simulated occipital cortex SUV “simu output” with = 0.06 min−1, model parameter from the bolus study; the estimated SUV “simu true” with = 0.096 min−1, suggested by the measured PI data; and the definition of steady state “ss”, which is ±5% of the plateau. The infusion scheme is unitless, and it shows the relative development of infusion with time.
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