Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen

Figure 6

The effects of oral AcSDKP on renal function in diabetic mice. Plasma cystatin C levels (a, b) and urine albumin/creatinine ratios (c, d) in STZ-induced diabetic mice (a, c) and db/db mice (b, d) are shown. Cystatin C in CD-1 mice, ; in db/db mice, were analyzed. For the urine albumin/creatinine ratio, 4 CD-1 mice and 4 or 5 db/db mice were analyzed. The data are expressed as the mean SEM in the figure.

(a)

(b)

(c)

(d)