Identification of Potential Key lncRNAs and Genes Associated with Aging Based on Microarray Data of Adipocytes from Mice

Table 2

Results of Gene Ontology functional and pathways enrichment analyses for genes positively regulated by differentially time-series expressed lncRNAs.

Category	Term	Adjust value	Gene count	Genes
GO-BP	Vasculature development [GO:0001944]		65	Adamts1, Cdh5, Ctsh, Cxcr3, Dhcr7, Edn1, Efna1, Efnb2, Notch3, Pdgfrb, and so on
GO-BP	Blood vessel development [GO:0001568]		60	Adamts1, Cdh5, Ctsh, Cxcr3, Dhcr7, Edn1, Efna1, Efnb2, Notch3, Pdgfrb, and so on
GO-BP	Regulation of locomotion [GO:0040012]		51	Dab2, Ifitm3, Il16, Il33, Irs2, Megf8, Myo1f, Pdgfrb, Pecam1, Pkn1, and so on
GO-BP	Blood vessel morphogenesis [GO:0048514]		49	Adamts1, Aqp1, C3, Ccr2, Edn1, Efna1, Efnb2, Egfl7, Elk3, Ephb4, and so on
GO-BP	Regulation of cellular component movement [GO:0051270]		50	Ccl21a, Dab2, Ddr2, Dpep1, Efna1, Nup155, Pde4d, Pdgfra, Pdgfrb, Pecam1, and so on
GO-CC	Cell surface [GO:0009986]		53	Ackr3, Alcam, Cd200r1, Cd3e, Dpp4, Enpp1, Flt3l, Heg1, Ifitm3, Il2rb, and so on
GO-CC	Plasma membrane [GO:0005886]		158	Ano1, Antxr1, Aqp1, Capn3, Ccr2, Itga5, Itm2c, Kcnab1, Kcnn3, Kcnt2, and so on
GO-CC	Cell periphery [GO:0071944]		163	Antxr1, Aqp1, Bcas3, Capn3, Eps15l1, Ezr, Krt19, Lime1, Ntn4, P2rx4, and so on
GO-CC	Side of membrane [GO:0098552]		33	Alcam, Ano1, Cd74, Ikbkb, Il2rb, Itga5, Kdr, Ly6a, Ly6c1, Pkp4, and so on
GO-CC	Plasma membrane part [GO:0044459]		101	Klri1, Lime1, Ly6a, Npc1, P2rx4, Sema6a, Sept2, Tspan15, Upk1b, Zdhhc2, and so on
REACT_208531	Cholesterol biosynthesis		9	Cyp51, Dhcr7, Fdps, Hsd17b7, Idi1, Lss, Mvk, Sc5d, Sqle
REACT_198996	Elastic fibre formation		11	Efemp1, Efemp2, Fbln1, Fbln2, Fbln5, Furin, Itga5, Loxl1, Ltbp1, Mfap3, and so on

The GO-BP terms in the table are the top 5 ones with a higher adjusted value. DE-lncRNA, differentially time-series expressed long noncoding RNA gene; GO, Gene Ontology; BP, biological process; CC, cellular component. “REACT” terms are the pathway terms.