Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus
Table 3
Analyses of association between CR2 gene polymorphisms and the risk of ONFH in SLE patients.
SNP rs number
Genotype
Frequencies (%)
Allele
Dominant
Recessive
Controls (SLE)
Cases (SLE_ONFH)
OR (95% CI)
OR (95% CI)
OR (95% CI)
rs3813946
TT
102 (71.83)
35 (71.43)
CT
39 (27.46)
10 (20.41)
1.33 (0.73–2.45)
0.353
1.02 (0.50–2.10)
0.957
12.5 (1.37–115)
CC
1 (0.7)
4 (8.16)
rs311306
GG
108 (72.97)
35 (70.0)
CG
39 (26.35)
10 (20.0)
1.56 (0.86–2.81)
0.141
1.16 (0.57–2.34)
0.685
16.3 (1.86–143)
CC
1 (0.68)
5 (10.0)
rs1567190
TT
49 (33.11)
22 (44.0)
CT
74 (50.0)
22 (44.0)
0.72 (0.45–1.15)
0.164
0.63 (0.33–1.21)
0.165
0.67 (0.26–1.74)
0.411
CC
25 (16.89)
6 (12.0)
rs17615 (S639N)
GG
108 (73.47)
36 (73.47)
AG
39 (26.53)
10 (20.41)
1.28 (0.68–2.40)
0.450
1.0 (0.48–2.08)
1
AA
0 (0)
3 (6.12)
rs17045328
AA
78 (53.06)
31 (64.58)
AG
61 (41.5)
14 (29.17)
0.74 (0.43–1.29)
0.292
0.62 (0.32–1.22)
0.163
1.16 (0.30–4.55)
GG
8 (5.44)
3 (6.25)
rs12032512
CC
47 (31.76)
16 (32.0)
CG
78 (52.7)
23 (46.0)
1.14 (0.72–1.79)
0.587
0.99 (0.50–1.97)
0.975
1.53 (0.69–3.42)
0.295
GG
23 (15.54)
11 (22.0)
rs6690215
CC
41 (27.7)
20 (40.0)
CT
77 (52.03)
17 (34.0)
0.88 (0.55–1.38)
0.569
0.58 (0.29–1.12)
0.103
1.38 (0.65–2.92)
0.396
TT
30 (20.27)
13 (26.0)
rs17045468
CC
79 (53.74)
30 (60.0)
CT
61 (41.5)
17 (34.0)
0.87 (0.51–1.49)
0.616
0.78 (0.40–1.49)
0.442
1.28 (0.32–5.14)
TT
7 (4.76)
3 (6.0)
Genotype distributions are shown as number (%). Chi-square values and odds ratio (95% CI) are shown. OR: odds ratio; CI: confidence interval. Fisher’s exact test.
