Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus
Table 4
Analyses of association between CR2 gene haplotypes and the risk of ONFH in SLE patients.
Haplotype
Genotype
Frequencies (%)
Allele
Dominant
Recessive
SLE
SLE_ONFH
OR (95% CI)
OR (95% CI)
OR (95% CI)
Block1-ht1 T-G-C-G-A
−/−
46 (32.86)
22 (45.83)
ht1/−
71 (50.71)
21 (43.75)
0.66 (0.41–1.08)
0.10
0.58 (0.30–1.13)
0.106
0.59 (0.21–1.65)
0.313
ht1/ht1
23 (16.43)
5 (10.42)
Block1-ht2 T-G-T-G-G
−/−
74 (52.86)
31 (64.58)
ht2/−
58 (41.43)
14 (29.17)
0.73 (0.42–1.28)
0.275
0.62 (0.31–1.21)
0.158
1.1 (0.28–4.33)
1.0
ht2/ht2
8 (5.71)
3 (6.25)
Block1-ht3 T-G-T-G-A
−/−
96 (68.57)
28 (58.33)
ht3/−
38 (27.14)
13 (27.08)
1.8 (1.05–3.09)
0.031
1.56 (0.79–3.06)
0.196
3.81 (1.21–12.0)
ht3/ht3
6 (4.29)
7 (14.58)
Block1-ht4 C-C-T-A-A
−/−
101 (72.14)
35 (72.92)
ht4/−
39 (27.86)
10 (20.83)
1.24 (0.66–2.33)
0.512
0.96 (0.46–2.01)
0.918
ht4/ht4
0 (0.0)
3 (6.25)
(i) SNP order of haplotypes: rs3813946 (T/C)-rs311306 (G/C)-rs1567190 (T/C)-rs17615 (G/A)-rs17045328 (A/G). (ii) Haplotype distributions are shown as number (%). Chi-square values and odds ratio (95% CI) are shown. OR: odds ratio; CI: confidence interval. (iii) Fisher’s exact test.
