| | Reference | Comparison | Tissue/cells | Selected genes |
| | [10] | HD versus PD versus CKD | PBMC | Upregulated in HD | | ATOX1, RELA, CSDE1, MIF, LTB4R, GSS, NFRKB | | Upregulated in PD | | HRH1, OLR1, CHST4, S100A8, CXCL12, GPX7 | | Upregulated in CKD | | IL8RB, HDAC5, BCL6 P |
| | [73] | PRE-HD versus POST-HD | Blood | Upregulated POST-HD | | TNF-A, IL-8, IL-18, IL-1RN, IL-4R, IL-10R, IFN-γR1, CX3CR1, CXCR4, CCR7, C3aR1 | | HD high CRP versus HD low CRP | Upregulated in the low CRP group | | IL-1RN, IL-4R, IL-10R, IFN-γR1, CX3CR1, CXCR4, CCR7 |
| | [74] | HD versus HS | Muscle | Upregulated in HD | | SP3, MEF2A, MAF, TCF8, SMARCA1, DICER1, SFRS11, HMGN3, UPF3A, EPM2A, SOS2, DEK, CLK1, CDC10, LAF4, BMI1, DDX17, MAPK6, ANAPC13, MYBPC1, C6orf111, KIAA0740, ART3, BIRC2, RABGGTB, OA48-18, CSE1L, SH3GLB1, MAP2K4, GLRX, PIP5K3, SLC35A1, VPS26, PXMP1, SRP54, SCP-2, SUCLA2, DMD, PRDX3, NDUFA5, NRIP1, XPO1, PSMC6, SEPP1, AXOT, LANCL1, SHOC2, FAM8A1, UBE1C, UBL3, PJA2, YME1L1, ELF2, OGT, IRS1, GATM, DLD, BZRP, PICALM, CAST, ANGPT1, ANK3, AKAP9, Rif1, CBX3, CBX1, ZNF146, MYH8, Tl132, MORC3, ZC3H11A, PURA, FLJ13110, GBAS, KTN1, SLC30A9, Tre | | Downregulated in HD | | PTK9L, IGFBP4, TRAP1, TAX1BP3, LGALS3BP, GNAI2, HBA1, HBB | | PRE-HD versus POST-HD | Upregulated in POST-HD | | FST, GADD45A, GADD45B, IGFBP4, SAT, C-FOS, JUN-B, THBD, HES1, CCL2, CEBPD, BTG2, FOSL2, MYC, THBD, ZFP36, JE, NFIL3, SERPINB1, SCL39A14, NNMT, ARID5B | | Downregulated in POST-HD | | TOB1 |
| | [75] | semisynthetic versus full-synthetic dialysis membrane | PBMC | Upregulated in HD using semisynthetic membranes
Immunity: ABCC5, ALOX12, CAMP, CCL2, CCR1, CD163, CLEC1B, CSF1R, CSF3R, CTSS, EPHX1, F2, FCGR1A, FGCR2B, GAB3, GBP1, GZMA, HLA-DQB1, HLA-DRB1, HLA-E, IRF7, ITGB1, KLRB1, LGALS9, LILRB3, LRRK2, LTB, MS4A2, PF4, PHCA, PPARA, PTPRC, RGS1, S100A8, SLA, TAP2, TGIF, TNFRSF8, XRCC6. Signal transduction: ABI3, ADRBK2, ARHGAP30, CCL2, CCR1, CENTA1, CHES1, CLEC1B, CSF1R, CSF3R, DOCK10, DTX4, ERBB3, FAS, FCGR1A, FCGR2B, FLJ23834, FPR1, GAB3, GABBR1, IFT140, ITGB1, LATS2, LILRA2, LILRB3, LIMS1, LRRK2, LTB, LTBP1, MAPK8, MS4A2, MYLK, NCF1, NRTN, P2RY13, PF4, PLCB2, PPARA, PTPN7, PTPRC, RAB9A, RASSF4, RGS1, RGS18, RGS6, SLA, SOCS3, TGIF, TNFRSF8, WSB2, WWTR1. Macrophage-mediated immunity: CD163, FCGR1A, FCGR2B, GAB3, GBP1, LTB, PF4, S100A8, TGIF. Natural killer cell-mediated immunity: CLEC1B, FCGR1A, FCGR2B, GZMA, KLRB1, LILRB3, LTB. T-cell-mediated immunity: CTSS, GAB3, GZMA, HLA-DQB1, HLA-DRB1, HLA-E, LTB, SLA, TNFRSF8. Cell motility: ABI3, CCR1, CSF1R, DOCK10, FPR1, ITGB1, LIMS1, LTBP1, PF4, S100A8, TUBB1. Cell surface receptor-mediated signal transduction: ADRBK2, CCL2, CCR1, CENTA1, CHES1, CSF1R, CSF3R, DTX4, ERBB3, FAS, FPR1, GAB3, GABBR1, IFT140, LIMS1, LTB, MS4A2, P2RY13, PF4, PLCB2, RGS1, RGS18, RGS6, SLA, TGIF, TNFRSF8. Apoptosis: FAS, GZMA, LGALS9, MYBL2, NAIP, NALP1, PDCD5, PF4, RASSF4, SOCS3, STK17B, TGIF. Intracellular protein traffic: CAMP, CD163, COMT, DOCK10, ERO1 L, IFT140, MX1, RAB9A, RASSF4, RIN1, RTN4, SSR2, STON2, STX5, TRAK2, TUBB1, YIPF5. Other metabolisms: AKR1C3, CA2, COMT, CRSP2, DIO2, GNPNAT1, MAP3K14, NEK2, PHCA, SLC27A3, SNAPC3. Cell cycle and cell cycle control: CCNB2, CYR61, EGFR, FOXF2, HTLF, JUN, KIF11, NBR2, TTK, TUBD1, UHRF1, WEE1 |
| | [76] | PMN stimulated with shredded hollow fibres of CU or PS versus unstimulated PMN | PMN | Upregulated in PMN stimulated with shredded hollow fibres of CU or PS | | AXUD1, FTH1, LIF, PTGS2, MGC12815, IL-1b, CCL3, CXCL1, SOCS3, PPIF, SPAG9, ACPP, DCT, GLA, GNS, PFKFB3, PLAU, USP36, SFRS3, DDX48, FLJ23231, PTD004, GNA13, HBEGF, DPYSL3, ARL8, GPR4, RASL11, DUSP2, EDN1, EDN3, EDNRB, JUN, FOS, EGR1, EGR2, DDIT3, EGR3, ELL2, NR4A3, TFAP2A, STAR, SEC31L1, ATP13A3, PHACTR1, TncRNA | | Downregulated in PMN stimulated with shredded hollow fibres of CU or PS | | FADD, FLI1, SOLH, YPEL3 | | PMN stimulated with E. Coli versus unstimulated PMN | Upregulated in PMN stimulated with E. Coli | | GADD45B, BIRC3, IER3, IER5, SGK, CDH24, ICAM1, CSF1, VEGF, NBS1, CCL18, CCL20, CCL3, CD48, CXCL1, CXCL2, CXCL3, IL1A, IL1B, IL1RN, LIF, MGC12815, NFIL3, PTGS2, SOCS3, TNF, TNFAIP6, EGR1, EGR2, ETS2, HIVEP1, ISL1, JUN, MAFF, MAFG, NFKB1, NFKBIA, NFKBIE, NFKBIZ, NR4A3, TFAP2A, TNFAIP3, XBP1, ZFHX1B, B4GALT5, DCT, FPGS, GCH1, GLA, GNPDA1, LOC285533, OAZIN, PLAU, PPIF, PPP1R15B, DDX48, FLJ23231, NMES1, SFMBT2, SNAPC3, TIFA, PHACTR1, ARL8, CALCA, CDC42EP3, DPYSL3, DUSP2, EDN1, EDN3, EHD1, GAB2, GPR4, MAPK6, NSMAF, SLC35B2, RHCG, SPAG9, VANGL1, VPS18, KCNJ2, AQP9 | | Downregulated in PMN stimulated with E. Coli | | FADD, LAMB1, MEF2C, HNRPUL1, NDP52, YPEL3, DUSP6 | | PMN stimulated with E. Coli versus PMN stimulated with HD membrane | Upregulated in PMN stimulated with E. Coli | | CCL20, CXCL3, CCL3, IL1A, TNF, NFKBIA, NFKBIE, NFKBIZ, NFKB1, TNFAIP3, PLAU, IER5, ICAM3 |
| | [29] | HD versus CKD III-IV | PBMC | Upregulated in HD
AIF1, ATRN, BCL2, C1QBP, CADM1, CCL3, CD163, CD1D, CD300C, CD4, CD58, CD83, CD86, CEBPG, CLEC2B, CLEC4A, CLEC5A, CNIH, CTSC, CTSS, CXCL2, CXCL3, DNAJC8, EREG, FCAR, FTH1, FUS, GPR183, GPR65, GZMA, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ICOS, IFI30, IFI44, IGBP1, IL15, IL6ST, IL8, ILF2, ITGB1, ITGB2, KLRB1, KLRC1, KLRC3, KLRD1, KLRF1, LILRB2, LY86, LY96, NFIL3, PLA2G7, POMP, PRKRA, PTGER4, PTX3, RGS1, SAMHD1, SH2D1A, SIK1, SPN, TNFRSF25, TNFSF13, TNFSF8, VIPR1, XCL1, YTHDF2
Downregulated in HD
ACSL1, AIM2, ALOX15, ALOX5AP, ANXA11, APOL2, AQP9, ARHGDIB, ATP6V0A2, B2M, BCL2, C4A, CD24, CD27, CD2BP2, CD40, CD40LG, CD53, CD59, CD70, CD80, CD8B, CD97, CEACAM8, CNOT1, CNR2, DCLRE1C, DPP8, ELF4, FAIM3, FASLG, FCGR2A, FCGR2C, FCGR3A, FCGR3B, FYB, GBP1, GEM, GPR44, GPR68, GPSM3, GTF2I, GTPBP1, HLA-A, HLA-B, HLA-C, HLA-DOB, HLA-DPA1, HLA-DRB1, HLA-E, HLA-F, HLA-G, IFI16, IFI44, IFIT2, IFIT3, IFITM1, IFITM2, IFITM3, IGHA1, IGHD, IGHG1, IGKC, IGLL3P, IKBKG, IL16, IL18RAP, IL1A, IL1R1, IL1R2, IL1RAP, IL1RN, IL2RG, IL6R, IL7R, ILT4, IRF1, IRF2, IRF9, KIR2DL1, KLRG1, KRT1, LAT, LAT2, LILRA2, LILRB3, LSP1, LST1, LTF, LY9, LYST, MADCAM1, MAPRE2, MASP2, MBP, MNDA, MR1, MX2, MYD88, NCF2, NCF4, NCR2, NOTCH1, OASL, OTUB1, PGLYRP1, PLUNC, PSMB9, PSME1, PTAFR, PYHIN1, REG3A, S100A9, S1PR4, SECTM1, SEMA4D, SERPINA1, SIT1, SLC11A1, SLC4A1, ST6GAL1, TAPBP, TARP, TGFB2, TLR2, TLR6, TNFAIP6, TNFRSF13B, TNFRSF25, TNFRSF9, TNFSF10, TNFSF14, TOLLIP, TRAC, TRBC1, TRBC2, TREM1, TYROBP |
| | [77] | HD versus HS | Blood | Upregulated in HD
MORN1, FGF18, ZNF205, ADARB1, GLTSCR2, SAP30L, ODF3B, SRCRB4D, TNPO2, MAPRE3, DUX4, RUNX3, PCGF5, GPR144, MAPK8IP2, ZFPL1, PLEKHG5, ELAVL3, FBXO44, UBE2J2, IL34, SLC25A37, SFTPC, PDLIM7, ARMC5, PLEKHN1, GNAS, EPN1, BCL2, CHCHD5, TFRC, RPS11, LMNA, CYP11B2, TMEFF2, GP1BB, TRIM8, VRTN
Downregulated in HD
ATP2A3, MESDC1, FBRSL1, RNF19B, ATPIF1, FKBP1A, ILF3, RBBP4, PEBP1, CTBP1, HINT1, KLHL24, KDM1B, MTA1, KCTD5, CCDC115, SLC23A2, ACAD8, RAB11FIP4, RNF19B, NONO, TNRC6A, NDUFB8, OGT, ATP5C1, MARCH5, PPP1R8, RALGAPB, IRF2, ESYT2, BHLHE40, RABGAP1, GABPB2, QKI, FLI1, RAB7A, PDCD4, BCL9L, RNF166, ACTL6A, S1PR1, GLUD1, CCDC88C, CSAD, ADSS, SRSF1, LOC93622, ACLY, PRF1, MAPK9, KLF7, PIK3IP1, TRIB2 |
| | [78] | Mice with intraperitoneal injection of chlorhexidine gluconate versus control | Parietal peritoneum | Upregulated in parietal peritoneum treated with chlorhexidine gluconate
PTGS2, COL8a1, Ddx3y, EIF2S3Y, ADAM12, Il6, CXCL1, MMP14, CCL7, ANKRD1, LRRC15, CCL2, G1p2, RUNX1, IRF7, CTHRC1, CYP7B1, PTN, COL5A2, FN1, CSPG2, THBS1, MS4A4C, LOX, GDF15, DNM3OS, RIAN, WISP1, SFRP1, COL3A1, STAT2, OASL2, TNC, NCAM1, ITGA5, TRIB3, GJA1, IFIT2, SERPINA3N, LOXL2, GLIPR2, OASL1, TIMP1
Downregulated in parietal peritoneum treated with chlorhexidine gluconate
IGH4 |
| | [79] | PD/HD versus CKD III-IV/HS | PBMC | Upregulated in HD/PD
B4GALT1, ANG, B3GNT2, CHPF2, CHST11, CHST2, CHSY1, CSGALNACT2, DSE, ERBB2IP, GNS, GUSB, HBEGF, HEXA, HEXB, HPSE, HS2ST1, RPL29, SGSH, SMC3, SOD1, TGFB1, VCAN, VEGFA, XYLT1
Downregulated in HD/PD
COL4A3, ACAN, AGRN, B3GNT1, B4GALT1, B4GALT3, B4GALT7, CHI3L1, COL7A1, CHPF, CHST1, B4GALT7, CHST15, CHST3, CHST8, COL13A1, COL18A1, COL1A2, COL5A3, COL9A2, DMD, DST, EXTL3, FBLN1, FMOD, GALNS, HABP2, HDGF, HEXA, IDS, LAMA2, LTBP2, NID2, LTBP4, MATN1, NAGLU, NDST1, NID2, PI3, PRSS1, SGCD, SNTB2, ST3GAL2, TGFB1, THBS4, TNFAIP6 |
| | [9] | HD versus CKD II-III versus HS | PBMC | Upregulated in HD
LSM3, TNFAIP3, JUNB, SFRS10, KLF4, MBD2, RPL36A, CLEC2B, CDV3, HMGN3, DNTTIP2, H3F3B, ZC3H15, TAF9, UQCRB, SNRPG, DBI, NDUFB1, UQCRH, COX6C, EEF1B2, NDUFA6, LOC732102, NDUFS5, HMGB1, DBI, TINP1, ATP5I, ATP5O, PFDN5, ATP5J, RPL23, RPS7, RPL34, TAX1BP1, PSMA6, SNRPE, HSP90AA1, ATG5, NDUFA1, AIF1, LSM7, NPM1, COX7C |
| | [80] | HD versus HS | PBMC | Upregulated in HD
CASP1, NLRP3, NAIP5
Downregulated in HD
NLRP1, TXNIP, CARD8, |
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