Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction

Figure 2

DBT attenuated tubulointerstitial injury, extracellular matrix (ECM) deposition, and expression of Col I in the obstructive kidneys after UUO. Tubulointerstitial injury in the obstructive kidneys (HE staining of rats’ kidney sections, ×400). Tubular dilatation, tubular atrophy, tubular epithelial cells vacuolization, interstitial inflammatory cells infiltration, and interstitial fibrosis were observed in rats with UUO. Treatment with DBT and enalapril attenuated these changes (a). Deposition of ECM in the obstructive kidneys (Masson staining of rats’ kidney sections, ×400). Rats in UUO group showed increased deposition of ECM. Treatment with DBT and enalapril attenuated these changes (b). Col I deposition in the obstructive kidneys (immunohistochemistry, in brown, ×400). Rats in UUO group showed an obvious Col I staining. Treatment with DBT and enalapril attenuated these changes (c).

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(b)

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