Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction

Figure 6

DBT inhibited the mRNA expression of NLRP3, ASC, caspase-1, and pro-IL-1β in UUO rats by real-time PCR. Typical results are shown. In UUO group, NLRP3, ASC, caspase-1, and IL-1β were all significantly elevated. DBT and enalapril treatment decreased their expression (a, b, c, d). There were no differences between DBT and enalapril group, except for the expression of IL-1β mRNA. DBT showed better significant effects on inhibiting the expression of pro-IL-1β mRNA compared to enalapril (d). All data were presented as means ± SD, ( versus sham group; versus UUO group; and versus enalapril group).

(a)

(b)

(c)

(d)