Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders
Table 2
Predictive values for ASDs based on the three compounds.
Test
True positive (sensitivity)
False negative (1 − sensitivity)
True negative (specificity)
False positive (1 − specificity)
Total
Criteria
HPHPA > 101.5 mmol/mol creatinine
Control
61 (98.4%)
1 (1.6%)
62
ASDs
45 (72.6%)
17 (27.4%)
62
Criteria
3HPA > 45.2 mmol/mol creatinine
Control
62 (100%)
0 (0%)
62
ASDs
18 (29%)
44 (71%)
62
Criteria
3HHA > 14.8 mmol/mol creatinine
Control
60 (96.8%)
2 (3.2%)
62
ASDs
21 (33.9%)
41 (66.1%)
62
Criteria
Prediction probability > 0.65 (based on the three metabolites)
