A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

Figure 2

In Tpr-Met mice, progressive concentric hypertrophy leads to reduced body weight and food intake. Tpr-Met mice showed a significant decrease in body weight (BW) (a), body weight gain (b), and daily food intake (c). Tpr-Met mice showed marked decrease in body weight starting from postnatal day 20 (P20) and food intake starting from postnatal day 22 (P22). ; ; .

(a)

(b)

(c)