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BioMed Research International
Volume 2016, Article ID 9549036, 13 pages
Research Article

A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

1Department of Oncology, University of Turin, 10126 Turin, Italy
2Department of Medical Sciences, University of Turin, 10126 Turin, Italy
3FPO-IRCCS, 10060 Candiolo, Italy
4Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy

Received 22 January 2016; Accepted 5 April 2016

Academic Editor: Oreste Gualillo

Copyright © 2016 Valentina Sala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Gene expression profiling was performed on GSN muscle samples from cachectic Tpr-Met mice and littermate controls. A cut-off of p<0.05 and fold change > 1.7 was used, and 107 differentially expressed genes were identified. Among these, 63 were downregulated and 44 genes were upregulated. The complete gene list is reported in Supplementary Tables 1 and 2.

  1. Supplementary Material