A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

Table 1

Enriched GO molecular function (MF) and biological process (BP) categories in down- and upregulated genes (fold change > 1.7; ). Only categories significantly associated ( value < 0.05) are considered. The name and number of gene ontology (GO) categories, number of enriched genes, raw and corrected values, frequency in the gene set, and the corresponding gene list are reported.

GO category	Number of genes	Raw value	Correct value	Frequency in set (%)	Gene list
Gene set: downregulated genes
Translation factor activity, nucleic acid binding, GO:0008135	4		0.008	6.3	Tufm, Eif2ak1, Eif2s3y, and Eef1a2
Transferase activity, GO:0016740	15		0.001	24.0	Pdk2, St3gal3, Acvr2b, Eif2ak1, Alpk3, Pygm, Cox10, Csnk1e, Dyrk1b, Camk2b, Gamt, Prkaca, Pfkm, Ndufa10, and Mark2
Regulation of system process, GO:0044057	4		0.04	6.3	Ryr1, Gaa, Prkaca, and Casq1
Regulation of multicellular organismal process, GO:0051239	7		0.04	11.0	Ryr1, Gaa, Gnas, Gamt, Prkaca, Csda, and Casq1
Regulation of metabolic process, GO:0019222	17		0.002	27.0	E2f2, Camta2, Med25, Csda, Ube2l3, Cited4, Capzb, Acvr2b, Hoxc9, Eif2ak1, Trim54, Mapt, Tsc2, Spnb1, Mier2, Gnas, and Jmjd3
Regulation of biological quality, GO:0065008	8		0.046	13.0	Ank1, ACVR2B, TSC2, SPNB1, RYR1, GAA, PFKM, and CAPZB
Porphyrin metabolic process, GO:0006778	4		0.001	6.3	Ank1, EIF2AK1, COX10, and SPNB1
Phosphotransferase activity, alcohol group as acceptor, GO:0016773	11		0.001	17.0	Pdk2, Acvr2b, Eif2ak1, Alpk3, Csnk1e, Dyrk1b, Camk2b, Prkaca, Pfkm, Ndufa10, and Mark2
Phosphate metabolic process, GO:0006796	11		0.001	17.0	Pdk2, Acvr2b, Eif2ak1, Alpk3, Csnk1e, Dyrk1b, Dusp23, Atp6v0a1, Camk2b, Prkaca, and Mark2
Organ development, GO:0048513	12		0.007	19.0	Hsp90ab1, Ank1, Acvr2b, Hoxc9, Alpk3, Dyrk1b, Tsc2, Gaa, Gnas, Gamt, Prkaca, and Csda
Nucleotide binding, GO:0000166	22		0.001	35.0	Hsp90ab1, Tufm, Pdk2, Adssl1, Eif2s3y, Alpk3, Eef1a2, Pfkm, Ndufa10, Ube2l3, Idh3a, Mark2, Acvr2b, Eif2ak1, Pygm, Csnk1e, Dyrk1b, A2bp1, Gnas, Camk2b, Prkaca, and Myo18a
Nitrogen compound metabolic process, GO:0006807	16		0.012	25.0	E2f2, Camta2, Adssl1, Cox10, Med25, Csda, Ndufa10, Cited4, Ank1, Eif2ak1, Hoxc9, A2bp1, Spnb1, Mier2, Atp6v0a1, and Gamt
Negative regulation of protein complex disassembly, GO:0043242	4		0.001	6.3	Trim54, Mapt, Spnb1, and Capzb
Negative regulation of biological process, GO:0048519	10		0.009	16.0	Eif2ak1, Trim54, Mapt, Eef1a2, Tsc2, Spnb1, Ryr1, Jmjd3, Csda, and Capzb
Muscle system process, GO:0003012	4		0.005	6.3	Camta2, Ryr1, Gaa, and Actn3
Heterocycle metabolic process, GO:0046483	6		0.006	9.5	Ank1, ADSSL1, EIF2AK1, COX10, SPNB1, and ATP6V0A1
Generation of precursor metabolites and energy, GO:0006091	8		0.001	13.0	Pygm, Cox10, Gaa, Atp6v0a1, Gnas, Pfkm, Ndufa10, and Idh3a
Cytoskeletal protein binding, GO:0008092	6		0.014	9.5	Trim54, Spnb1, Actn3, Palld, Plec1, and Capzb
Cellular protein metabolic process, GO:0044267	21		0.001	33.0	Hsp90ab1, Tufm, Pdk2, Eif2s3y, Alpk3, Cox10, Eef1a2, Dusp23, Ube2l3, Mark2, Acvr2b, Rnf123, St3gal3, Eif2ak1, Fbxw5, Csnk1e, Dyrk1b, Fbxo31, Camk2b, Jmjd3, and Prkaca
Cellular macromolecule catabolic process, GO:0044265	7		0.025	11.0	Rnf123, Pygm, Fbxw5, Gaa, Fbxo31, Pfkm, and Ube2l3
Cellular biosynthetic process, GO:0044249	17		0.005	27.0	Tufm, E2f2, Camta2, Adssl1, Eif2s3y, Cox10, Eef1a2, Med25, Csda, Cited4, St3gal3, Ank1, Hoxc9, Spnb1, Mier2, Atp6v0a1, and Gamt
Cation transport, GO:0006812	6		0.04	9.5	Kcnc1, Ank1, Ryr1, Cacnb1, Atp6v0a1, and Camk2b
Anatomical structure morphogenesis, GO:0009653	9		0.021	14.0	Acvr2b, Hoxc9, Cox10, Dyrk1b, Tsc2, Gaa, Gnas, Gamt, and Prkaca
GTPase activity, GO:0003924	4		0.015	6.3	Tufm, Eif2s3y, Eef1a2, Gnas
Gene set: upregulated genes
Response to stimulus, GO:0050896	15		0.001	34.0	Lyz1, Ccl21c, Ccl21a, Ccl9, Gja1, Adipoq, Ccl7, Lyzs, Cd83, Clec2d, Sepp1, Spon2, Scara5, Cd14, and Klf4
Response to external stimulus, GO:0009605	7		0.003	16.0	Ccl21c, Ccl21a, Ccl9, Gja1, Klf4, Cd14, and Ccl7
Receptor binding, GO:0005102	8		0.002	18.0	Ogn, Ccl21c, Ccl21a, Clec2d, Ccl9, Gja1, Adipoq, and Ccl7
Positive regulation of biological process, GO:0048518	8		0.03	18.0	Cd83, Tnfrsf12a, Ccl21a, Ccdc80, Gja1, Adipoq, Klf4, and Cd14
Locomotion, GO:0040011	6		0.003	14.0	Tnfrsf12a, Ccl21c, Ccl21a, Ccl9, Gja1, and Ccl7
Immune response, GO:0006955	6		0.007	14.0	Ccl21c, Ccl21a, Ccl9, Spon2, Cd14, and Ccl7
Defense response, GO:0006952	7		0.002	16.0	Lyz1, Ccl21c, Ccl21a, Clec2d, Lyzs, Cd14, and Ccl7
Chemokine activity, GO:0008009	4		0.001	9.1	Ccl21c, Ccl21a, Ccl9, and Ccl7