A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

Table 2

Enriched KEGG pathways in down- and upregulated genes (fold change > 1.7; ).Only categories significantly associated ( value < 0.05) are considered. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, number of enriched genes, value, enrichment factor, and list of the genes enriched in each pathway are reported.

KEGG pathway	Number of genes	value	Enrichment factor	Gene list
Gene set: downregulated genes
Tight junction	2		8.0	Actn3, Csda
Melanogenesis	3		16.5	Camk2b, Gnas, and Prkaca
Long-term depression	2		14.3	Ryr1, Gnas
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2		15.0	Cacnb1, Actn3
GnRH signaling pathway	3		17.0	Camk2b, Gnas, and Prkaca
Prostate cancer	2		12.2	Hsp90ab1, E2f2
Gap junction	2		12.2	Gnas, Prkaca
Galactose metabolism	2		42.4	Gaa, Pfkm
Glioma	2		16.1	E2f2, Camk2b
Dilated cardiomyopathy	3		18.4	Cacnb1, Gnas, and Prkaca
Metabolic pathways	9		4.34	Adssl1, St3gal3, Cox10, Gaa, Atp6v0a1, Gamt, Pfkm, Ndufa10, and Idh3a
Oxidative phosphorylation	3		10.9	Cox10, Atp6v0a1, and Ndufa10
Calcium signaling pathway	4		11.9	Ryr1, Camk2b, Gnas, and Prkaca
Insulin signaling pathway	3		12.2	Pygm, Tsc2, and Prkaca
Lysosome	2		9.61	Gaa, Atp6v0a1
Taste transduction	2		19.1	Gnas, Prkaca
Progesterone-mediated oocyte maturation	2		10.5	Hsp90ab1, Prkaca
Parkinson’s disease	2		6.89	Ube2l3, Ndufa10
Long-term potentiation	2		14.9	Camk2b, Prkaca
Hedgehog signaling pathway	2		20.8	Csnk1e, Prkaca
Wnt signaling pathway	3		10.8	Csnk1e, Camk2b, and Prkaca
Vascular smooth muscle contraction	2		8.94	Gnas, Prkaca
MAPK signaling pathway	3		6.11	Mapt, Cacnb1, and Prkaca
Starch and sucrose metabolism	2		25.4	Pygm, Gaa
Gene set: upregulated genes
Chemokine signaling pathway	4		16.2	Ccl21c, Ccl21a, Ccl9, and Ccl7
Cytokine-cytokine receptor interaction	5		16.2	Tnfrsf12a, Ccl21c, Ccl21a, Ccl9, and Ccl7