Review Article

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

Table 3

List of macrophage genes whose activity changes in the accumulation of intracellular cholesterol.

GeneMoleculeFunctions

FCGBPFc fragment of IgG binding protein Immune response
S100A8S100 calcium binding protein A8 Immune response, migration, cell body formation
ITLN1Intelectin 1 (galactofuranose binding) Pathogen metabolism
NCOR2Nuclear receptor corepressor 2 Immune response
TPPP3Tubulin polymerization-promoting protein family member 3 Cell body formation
AKR1C1Aldo-keto reductase family 1, member C1 Immune response
FAM65AFamily with sequence similarity 65, member A Cell body formation
HECTD2HECT domain containing E3 ubiquitin protein ligase 2 Metabolism
RD3Retinal degeneration 3 Nerve features
TNFSF18Tumor necrosis factor (ligand) superfamily, member 18 Immune response, migration
NEURL3Neuralized E3 ubiquitin protein ligase 3 Metabolism
CD209CD209 molecule Immune response, migration, dendritic cell features
STRIP2Striatin interacting protein 2 Cell body formation
CCL4L2Chemokine (C-C motif) ligand 4-like 2 Migration
TJP2Tight junction protein 2 Migration
SPON2Spondin 2, extracellular matrix protein Migration
L1CAML1 cell adhesion moleculeMigration
ARHGEF16Rho guanine nucleotide exchange factor (GEF) 16 Migration
NESNestin Cell body formation, nerve features
F3Coagulation factor III (thromboplastin, tissue factor) Migration
GALNT5Polypeptide N-acetylgalactosaminyltransferase 5 Metabolism
MT1EMetallothionein 1E Metabolism
COQ2Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Metabolism
TRIM54Tripartite motif containing 54 Cell body formation
ANKRD63Ankyrin repeat domain 63 Cell body formation
CCL24Chemokine (C-C motif) ligand 24 Immune response, migration
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3 Immune response
NETO2Neuropilin (NRP) and tolloid- (TLL-) like 2 Nerve features
CCL4Chemokine (C-C motif) ligand 4 Immune response, migration
ACPPAcid phosphatase, prostate Metabolism
STARD4StAR-related lipid transfer (START) domain containing 4 Metabolism
RANBP10RAN binding protein 10 Cell body formation
ROBO2Roundabout guidance receptor 2 Migration, nerve features
CHL1Cell adhesion molecule L1-like Migration, nerve features
RARARetinoic acid receptor, alpha Negative regulation of interferon-gamma production; positive regulation of interleukin-4 production, immune response
SLC16A9Solute carrier family 16, member 9 Metabolism
HTR2A5-Hydroxytryptamine (serotonin) receptor 2A, G-protein-coupled Nerve features
BCAR1Breast cancer antiestrogen resistance 1 Migration
OR6K3Olfactory receptor, family 6, subfamily K, member 3 Nerve features
CYP7B1Cytochrome P450, family 7, subfamily B, polypeptide 1 Metabolism