TY - JOUR A2 - Kunert-Keil, Christiane AU - Świdziński, Teodor AU - Linkowska-Świdzińska, Kamila AU - Czerniejewska-Wolska, Hanna AU - Wiskirska-Woźnica, Bożena AU - Owecki, Maciej AU - Głowacka, Maria Danuta AU - Frankowska, Anna AU - Łącka, Katarzyna AU - Glapiński, Mariusz AU - Maciejewska-Szaniec, Zofia AU - Świdziński, Piotr PY - 2016 DA - 2016/08/30 TI - Hypothyroidism Affects Olfactory Evoked Potentials SP - 9583495 VL - 2016 AB - Background. Objective electrophysiological methods for investigations of the organ of smell consist in recordings of olfactory cortex responses to specific, time restricted odor stimuli. In hypothyroidism have impaired sense of smell. Material and Methods. Two groups: control of 31 healthy subjects and study group of 21 with hypothyroidism. The inclusion criterion for the study group was the TSH range from 3.54 to 110 μIU/mL. Aim. Assessment of the latency time of evoked responses from the olfactory nerve N1 and the trigeminal nerve N5 using two smells of mint and anise in hypothyroidism. Results. The smell perception in subjective olfactory tests was normal in 85% of the hypothyroid group. Differences were noticed in the objective tests. The detailed intergroup analysis of latency times of recorded cortical responses PN5 and PN1 performed by means between the groups of patients with overt clinical hypothyroidism versus subclinical hypothyroidism demonstrated a significant difference (p<0.05) whereas no such differences were found between the control group versus subclinical hypothyroidism group (p>0.05). Conclusion. We can conclude that registration of cortex potentials at irritation of olfactory and trigeminal nerves offers possibilities for using this method as an objective indicator of hypothyroidism severity and prognostic process factor. SN - 2314-6133 UR - https://doi.org/10.1155/2016/9583495 DO - 10.1155/2016/9583495 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -