Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 9694289, 9 pages
http://dx.doi.org/10.1155/2016/9694289
Research Article

Ratio of Circulating IFNγ+ “Th17 Cells” in Memory Th Cells Is Inversely Correlated with the Titer of Anti-CCP Antibodies in Early-Onset Rheumatoid Arthritis Patients Based on Flow Cytometry Methods of the Human Immunology Project

Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan

Received 30 December 2015; Revised 11 April 2016; Accepted 19 April 2016

Academic Editor: Giacomina Brunetti

Copyright © 2016 Shigeru Kotake et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Kotake, Y. Nanke, M. Mogi et al., “IFN-γ-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL,” European Journal of Immunology, vol. 35, no. 11, pp. 3353–3363, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Kotake, N. Udagawa, N. Takahashi et al., “IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis,” The Journal of Clinical Investigation, vol. 103, no. 9, pp. 1345–1352, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. Yao, S. L. Painter, W. C. Fanslow et al., “Human IL-17: a novel cytokine derived from T cells,” The Journal of Immunology, vol. 155, no. 12, pp. 5483–5486, 1995. View at Google Scholar · View at Scopus
  4. K. Sato, A. Suematsu, K. Okamoto et al., “Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction,” The Journal of Experimental Medicine, vol. 203, no. 12, pp. 2673–2682, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Komatsu, K. Okamoto, S. Sawa et al., “Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis,” Nature Medicine, vol. 20, no. 1, pp. 62–68, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Raza, F. Falciani, S. J. Curnow et al., “Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin,” Arthritis Research & Therapy, vol. 7, no. 4, pp. R784–R795, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Kokkonen, I. Söderström, J. Rocklöv, G. Hallmans, K. Lejon, and S. R. Dahlqvist, “Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis,” Arthritis and Rheumatism, vol. 62, no. 2, pp. 383–391, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Chalan, B.-J. Kroesen, K. S. M. van der Geest et al., “Circulating CD4+CD161+ T lymphocytes are increased in seropositive arthralgia patients but decreased in patients with newly diagnosed rheumatoid arthritis,” PLoS ONE, vol. 8, no. 11, Article ID e79370, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Hirota, H. Yoshitomi, M. Hashimoto et al., “Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model,” The Journal of Experimental Medicine, vol. 204, no. 12, pp. 2803–2812, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. H. T. Maecker, J. P. McCoy, and R. Nussenblatt, “Standardizing immunophenotyping for the Human Immunology Project,” Nature Reviews Immunology, vol. 12, no. 3, pp. 191–200, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Kochi, Y. Okada, A. Suzuki et al., “A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility,” Nature Genetics, vol. 42, no. 6, pp. 515–519, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Hirahara, A. Poholek, G. Vahedi et al., “Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease,” Journal of Allergy and Clinical Immunology, vol. 131, no. 5, pp. 1276–1287, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Nakayamada, H. Takahashi, Y. Kanno, and J. J. O'Shea, “Helper T cell diversity and plasticity,” Current Opinion in Immunology, vol. 24, no. 3, pp. 297–302, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Cosmi, R. De Palma, V. Santarlasci et al., “Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor,” Journal of Experimental Medicine, vol. 205, no. 8, pp. 1903–1916, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Cosmi, R. Cimaz, L. Maggi et al., “Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis,” Arthritis and Rheumatism, vol. 63, no. 8, pp. 2504–2515, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Nistala, S. Adams, H. Cambrook et al., “Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 33, pp. 14751–14756, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Annunziato, V. Santarlasci, L. Maggi, L. Cosmi, F. Liotta, and S. Romagnani, “Reasons for rarity of Th17 cells in inflammatory sites of human disorders,” Seminars in Immunology, vol. 25, no. 4, pp. 299–304, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Yamada, Y. Nakashima, K. Okazaki et al., “Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 67, no. 9, pp. 1299–1304, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. I. Arroyo-Villa, M.-B. Bautista-Caro, A. Balsa et al., “Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti-CCP seropositivity,” PLoS ONE, vol. 7, no. 8, Article ID e42189, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. G. R. Burmester, P. Durez, G. Shestakova et al., “Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis,” Rheumatology (Oxford, England), vol. 55, no. 1, pp. 49–55, 2015. View at Publisher · View at Google Scholar
  21. M. C. Genovese, P. Durez, H. B. Richards et al., “Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study,” Annals of the Rheumatic Diseases, vol. 72, no. 6, pp. 863–869, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. M. C. Genovese, P. Durez, H. B. Richards et al., “One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study,” Journal of Rheumatology, vol. 41, no. 3, pp. 414–421, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. M. C. Genovese, M. Greenwald, C.-S. Cho et al., “A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors,” Arthritis & Rheumatology, vol. 66, no. 7, pp. 1693–1704, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. N. A. Daha and R. E. M. Toes, “Rheumatoid arthritis: are ACPA-positive and ACPA-negative RA the same disease?” Nature Reviews Rheumatology, vol. 7, no. 4, pp. 202–203, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Sellam, H. Hendel-Chavez, S. Rouanet et al., “B cell activation biomarkers as predictive factors for the response to rituximab in rheumatoid arthritis: a six-month, national, multicenter, open-label study,” Arthritis and Rheumatism, vol. 63, no. 4, pp. 933–938, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. H. van Dongen, J. van Aken, L. R. Lard et al., “Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial,” Arthritis and Rheumatism, vol. 56, no. 5, pp. 1424–1432, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. N. E. Aerts, K. J. De knop, J. Leysen et al., “Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migrationassociated chemokine receptor expression,” Rheumatology, vol. 49, no. 12, pp. 2264–2272, 2010. View at Publisher · View at Google Scholar · View at Scopus