Preparation of Thermosensitive Gel for Controlled Release of Levofloxacin and Their Application in the Treatment of Multidrug-Resistant Bacteria
Table 3
Hydrodynamic diameter (nm), mean distribution (%), and zeta potential (mV) of micelles composed of PL 407 or PL 108 isolated or in association with PL L-81 containing levofloxacin (LVF).
Formulations
25°C
37°C
Hydrodynamic diameter (nm)
Mean distribution (%)
Zeta potential (mV)
Hydrodynamic diameter (nm)
Mean distribution (%)
Zeta potential (mV)
F1
5.2 ± 0.1 39.8 ± 0.9
10.5 ± 0.9 89.5 ± 0.2
−15.30 ± 1.03
21.0 ± 0.6
100
−5.45 ± 0.34
F2
5.6 ± 0.2 46.0 ± 1.5
10.7 ± 1.1 89.3 ± 1.0
−15.70 ± 1.19
22.5 ± 1.7
100
−14.02 ± 0.54
F3
6.2 ± 0.1 467.8 ± 42.1
12.7 ± 0.2 87.3 ± 0.3
−3.62 ± 1.58
482.1 ± 20.2
100
−6.63 ± 0.85
F4
37.0 ± 0.1 492.1 ± 0.1
31.7 ± 0.1 62.7 ± 0.2
−2.57 ± 1.31
495.4 ± 3.2
98.3 ± 2.3
−2.54 ± 0.64
F1-L
552.4 ± 43.9
99.2 ± 0.8
−6.03 ± 0.63
333.2 ± 2.6
89.2 ± 12
−2.54 ± 0.64
F2-L
6.2 ± 0.06 458.4 ± 19.8
12.8 ± 0.2 87.2 ± 0.2
−16.60 ± 0.43
338.3 ± 6.7
95.8 ± 3.7
−16.60 ± 0.54
F3-L
552.3 ± 44.2
98.7 ± 1.2
−2.49 ± 0.65
539.8 ± 80.6
92.2 ± 7.6
−14.40 ± 0.45
F4-L
580.1 ± 0.1
93.1 ± 5.6
−1.90 ± 0.82
587.5 ± 4.9
93.1 ± 2.4
−6.24 ± 0.65
Note: data presented as mean ± standard deviation (/formulation).
