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BioMed Research International
Volume 2016, Article ID 9717530, 15 pages
Review Article

Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

1Department of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
2Department of Infectology and Dermatology, Riga Stradins University, Riga, Latvia
3Department of Dermatology, Christian-Albrechts-University Kiel, Kiel, Germany

Received 4 December 2015; Accepted 30 March 2016

Academic Editor: Arjen F. Nikkels

Copyright © 2016 Ieva Saulite et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.