Review Article

Zebrafish: A Versatile Animal Model for Fertility Research

Table 2

The reproductive effect of chemicals in zebrafish.

ChemicalsChemical toxicity effectReferences

Ammonium perchlorateReduced spawn volume[235, 236]

BisphenolsSkewed sex ratio in favor of females, imbalance of steroid hormones, reduced germ cell count, decreased hatching rates, and embryonic malformation[203, 237]

Brominated flame retardants (e.g., 2,4,6-tribromophenol and 2,4-dibromophenol)Skewed sex ratio, decreased fecundity, altered transcription of steroid genes and plasma concentration of sex hormones, disturbed gonad morphology, and complete hatching failure at high chemical dosage[53, 238, 239]

CobaltSperms with damaged DNA and reduced fertilization and embryo survival rates[240]

2,4-DichlorophenolAltered steroid gene expression and plasma sex hormone level and reduced number of eggs released and hatching rate[201]

Ethinyl estradiolReduced or complete failure of fertilization, reduced adult fecundity and vitellogenic response, abnormal vitellogenin induction, discernible effects on secondary sexual characteristics, altered sexual differentiation process, and degenerative sign of reproductive organs[241ā€“243]

Fluorotelomer alcoholsReduced eggs and sperms production, affected steroidogenesis along with altered plasma reproductive hormones level, and reduced hatching rates [202, 244]

Pharmaceutical drugsNegative impacts on several reproductive parameters: courtship behaviour, number of egg spawned, hatching success, HPG gene transcription and hormone level, and gonad histological changes along with germ cells qualities[245ā€“248]

Polychlorinated biphenylsReduced number of eggs released and fertilized, altered ovary histology, and skewed sex ratio[204, 249, 250]

Polycyclic musksAntiestrogenic effect[251]