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BioMed Research International
Volume 2016, Article ID 9782031, 8 pages
Research Article

Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea

1Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, China
2The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China

Received 25 September 2015; Revised 23 December 2015; Accepted 28 December 2015

Academic Editor: Hanrui Zhang

Copyright © 2016 Xiaoya Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, ), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, ), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, ), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, ) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (, ), AEA and AHI (, ), AEA and HOMA-IR (, ), and 1/2-AG and HOMA-IR (, ). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.