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BioMed Research International
Volume 2017, Article ID 1038984, 8 pages
https://doi.org/10.1155/2017/1038984
Research Article

Negative Correlation between miR-200c and Decorin Plays an Important Role in the Pathogenesis of Colorectal Carcinoma

1Shanghai Starriver Bilingual School, 2588 Jindu Road, Minhang District, Shanghai 201108, China
2Department of General Surgery, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China
3Shanghai Cinoasia Institute, Yangpu District, Shanghai 200437, China

Correspondence should be addressed to Hong-Qi Chen; moc.361@80nehcqh and Si-Bo Zhu; moc.aisaonic@uhzobis

Received 10 October 2016; Accepted 16 March 2017; Published 16 April 2017

Academic Editor: Stephen H. Safe

Copyright © 2017 Ren-Yi Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To demonstrate the regulatory role of miRNA in colorectal carcinoma (CRC) and reveal the transcript markers that may be associated with CRC clinical outcomes. Method. Herein, we analyzed both mRNA and miRNA gene expression profiles of 255 CRC tumor samples from The Cancer Genome Atlas project to reveal the regulatory association between miRNA and mRNA. Also, the potential role of gene coexpression network in CRC has been explored. Results. The negative correlation between miR-200c and DCN (Decorin) was calculated in CRC, indicating that DCN could be a potential target of miR-200c. Clinical features indicated that colon polyp history and overall survival were significantly related to the expression level of miR-200c. Three coexpression networks have been constructed, and genes involved in the networks are related to cell cycle, NOTCH, and mTOR signaling pathways. Conclusion. Our result provides a new insight into cancer related mRNA coexpression network in CRC research.