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BioMed Research International
Volume 2017, Article ID 1049602, 15 pages
https://doi.org/10.1155/2017/1049602
Review Article

Positive Effect of Higher Adult Body Mass Index on Overall Survival of Digestive System Cancers Except Pancreatic Cancer: A Systematic Review and Meta-Analysis

1Department of Radiation Oncology, Shandong Cancer Hospital and Institute Affiliated to Shandong University, Jinan 250000, China
2Department of Oncology, People’s Hospital of Rizhao, Rizhao 2768, China
3Department of Hematology, Qilu Hospital of Shandong University, Jinan 250000, China
4Department of Urology, Qilu Hospital of Shandong University, Jinan 250000, China
5Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250000, China

Correspondence should be addressed to Jinming Yu; moc.621@ncuygnimnij

Received 24 January 2017; Revised 27 May 2017; Accepted 31 May 2017; Published 29 August 2017

Academic Editor: Sabine Rohrmann

Copyright © 2017 Jie Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High body mass index (BMI) has been inconsistently associated with overall survival (OS) of digestive system cancers (DSCs). This meta-analysis was conducted to investigate whether high BMI was associated with DSCs prognosis. 34 studies were accepted, with a total of 23,946 DSC cases. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) for OS in BMI categories from individual studies were extracted and pooled by random-effect model. The overall HR of DSCs except pancreatic cancer for OS of adult overweight cases was 0.76 (95% CI = 0.67–0.85). DSC individuals except pancreatic cancer with adult obesity were at decreased risk for OS (HR = 0.85, 95% CI = 0.72–0.98). Among DSC patients except pancreatic cancer, the overall HR for the highest versus the lowest BMI category was 0.82 (95% CI = 0.71–0.92). Additionally, comparing the highest and lowest BMI categories, the combined HR of pancreatic cancer was 1.22 (95% CI = 1.01–1.43). Our meta-analysis suggested an increased OS among adult overweight and obese DSC survivors except pancreatic cancer. Overweight and obesity in adulthood may be important prognostic factors that indicate an increased survival from DSC patients except pancreatic cancer.