Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Figure 2

3xTgAD mice showed abnormalities in the elevated plus maze test and did not present depressive-like behavior in the tail suspension test at the age of 7-8 months. (a) In the elevated plus maze test, a reduction in locomotor activity was observed in 3xTgAD mice, which was not improved by citalopram. (b) In the elevated plus maze test, 3xTgAD mice spent more time in the open arms and citalopram did not take effect. (c) Representative traces of mice in the elevated plus maze test. (d) In the tail suspension test, 3xTgAD mice did not exhibit depressive-like behavior. Error bars indicate SEM. , .

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