Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Figure 5

Citalopram treatment decreased Aβ production by inhibiting APP expression in 3xTgAD mice. (a) The insoluble Aβ₄₀ concentrations in the hippocampus and cerebral cortex samples from citalopram-treated 3xTgAD mice were significantly lower than the concentrations in water-treated 3xTgAD mice. (b) Citalopram treatment did not have significant effect on the levels of insoluble Aβ₄₂ in the hippocampus and cerebral cortex. (c) Representative western blot images of APP and CTFβ in different groups. (d) Citalopram treatment downregulated APP expression in 3xTgAD mice. (e) Citalopram treatment decreased CTFβ levels in 3xTgAD mice. Error bars indicate SEM. , , and .

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