Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 1243515, 9 pages
https://doi.org/10.1155/2017/1243515
Research Article

Ethyl Acetate Extracts of Semen Impatientis Inhibit Proliferation and Induce Apoptosis of Human Prostate Cancer Cell Lines through AKT/ERK Pathways

1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Correspondence should be addressed to Yufeng Ding

Received 14 May 2016; Revised 21 December 2016; Accepted 27 December 2016; Published 13 March 2017

Academic Editor: Sung-Hoon Kim

Copyright © 2017 Tao Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Siegel, D. Naishadham, and A. Jemal, “Cancer statistics, 2012,” CA Cancer Journal for Clinicians, vol. 62, no. 1, pp. 10–29, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. P. D. Baade, D. R. Youlden, S. M. Cramb, J. Dunn, and R. A. Gardiner, “Epidemiology of prostate cancer in the Asia-Pacific region,” Prostate International, vol. 1, no. 2, pp. 47–58, 2013. View at Publisher · View at Google Scholar
  3. S. Wang, X. Wu, M. Tan et al., “Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy,” Journal of Ethnopharmacology, vol. 140, no. 1, pp. 33–45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia, vol. I, China Medical Scientific and Technological Press, Beijing, China, 2010.
  5. A. Sakunphueak and P. Panichayupakaranant, “Comparison of antimicrobial activities of naphthoquinones from Impatiens balsamina,” Natural Product Research, vol. 26, no. 12, pp. 1119–1124, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. Z.-S. Ding, F.-S. Jiang, N.-P. Chen, G.-Y. Lv, and C.-G. Zhu, “Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina,” Molecules, vol. 13, no. 2, pp. 220–229, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J.-A. Shin, M. H. Ryu, K.-H. Kwon, B. Choi, and S.-D. Cho, “Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines,” Journal of Oral Pathology and Medicine, vol. 44, no. 6, pp. 420–428, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. Y.-C. Wang and Y.-H. Lin, “Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.,” Fitoterapia, vol. 83, no. 8, pp. 1336–1344, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Lopez and S. W. G. Tait, “Mitochondrial apoptosis: killing cancer using the enemy within,” British Journal of Cancer, vol. 112, pp. 957–962, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. A. K. Taraphdar, M. Roy, and R. K. Bhattacharya, “Natural products as inducers of apoptosis: implication for cancer therapy and prevention,” Current Science, vol. 80, no. 11, pp. 1387–1396, 2001. View at Google Scholar · View at Scopus
  12. N. N. Danial, “BCL-2 family proteins: critical checkpoints of apoptotic cell death,” Clinical Cancer Research, vol. 13, no. 24, pp. 7254–7263, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. D. Courtney, R. B. Corcoran, and J. A. Engelman, “The PI3K pathway as drug target in human cancer,” Journal of Clinical Oncology, vol. 28, no. 6, pp. 1075–1083, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. L. S. Steelman, W. H. Chappell, S. L. Abrams et al., “Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mtor pathways in controlling growth and sensitivity to therapy-implications for cancer and aging,” Aging, vol. 3, no. 3, pp. 192–222, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Mukherjee, J. M. S. Bartlett, N. S. Krishna, M. A. Underwood, and J. Edwards, “Raf-1 expression may influence progression to androgen insensitive prostate cancer,” Prostate, vol. 64, no. 1, pp. 101–107, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. L. A. Allan, N. Morrice, S. Brady, G. Magee, S. Pathak, and P. R. Clarke, “Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK,” Nature Cell Biology, vol. 5, no. 7, pp. 647–654, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Cho, J. Shin, and K. Kwon, “AMPK-activated protein kinase activation by Impatiens balsamina L. is related to apoptosis in HSC-2 human oral cancer cells,” Pharmacognosy Magazine, vol. 11, no. 41, pp. 136–142, 2015. View at Publisher · View at Google Scholar
  18. T. Li, X. Zhao, Z. Mo et al., “Formononetin promotes cell cycle arrest via downregulation of akt/cyclin D1/CDK4 in human prostate cancer cells,” Cellular Physiology and Biochemistry, vol. 34, no. 4, pp. 1351–1358, 2014. View at Publisher · View at Google Scholar · View at Scopus