MicroRNA as a Therapeutic Target in Cardiac Remodeling

Figure 2

MicroRNAs (miRNAs) in cardiac hypertrophic pathways. Arrows colored in red indicate the functions of depression; arrows colored in green indicate the functions of activation. Abbreviations for mRNAs: AGTR1: angiotensin II receptor type 1; Camk2d: calcium/calmodulin-dependent protein kinase II delta; Cdc42: cell division cycle 42; c-Fos: proto-oncogene protein; CRT: calreticulin; Foxo3: Forkhead box O3; Gata4: GATA binding protein 4; GATA6: GATA binding protein 6; Grb2: growth factor receptor bound protein 2; Hdac4: histone deacetylase 4; HMGA1: high mobility group AT-hook 1; NFAT: nuclear factor of activated T cells; IGF-1: insulin-like growth factor 1; IGF-1R: insulin-like growth factor 1 receptor; Jarid2: jumonji and AT-rich interaction domain-containing protein 2; Ksr1: kinase suppressor of ras 1; LPA1: lysophosphatidic acid receptor 1; Mapk1: mitogen-activated protein kinase 1; Murf1: tripartite motif-containing 63; NCX1: sodium/calcium exchanger 1; Nfatc3: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; Pparγ: peroxisome proliferator-activated receptor γ; PTEN: phosphatase and tensin homolog; p300: E1A binding protein p300; Rab1A: Ras-related protein Rab 1a; Serca2a: Sarco/endoplasmic reticulum Ca²⁺-ATPase 2a; SIRT1: Sirtuin 1; SMAD4: SMAD family member 4; SORBS2: SH3 domain-containing protein 2; TGF-βR1: transforming growth factor β receptor 1; TNNI3K: troponin I type 3 interacting kinase; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; PKG: cGMP-dependent protein kinase; CAM: calmodulin; CTnT: cardiac troponin T; NPs: natriuretic peptides.