Endophytic Actinobacteria Associated with Dracaena cochinchinensis Lour.: Isolation, Diversity, and Their Cytotoxic Activities

Table 5

Antifungal, cytotoxic, and biosynthetic gene profiles of the 17 selected endophytic Actinobacteria isolated from D. cochinchinensis Lour.

Strain	Test pathogens			Cytotoxicity on MCF-7 (given in % inhibition)						Cytotoxicity on Hep G2 (given in % inhibition)						Biosynthetic genes
	Fusarium graminearum	Aspergillus carbonarius	Aspergillus westerdijkiae	Concentration (μg⋅ml^−1)
				10000	2000	400	80	16	IC50	10000	2000	400	80	16	IC50	PKS-I	PKS-II	NRPS
HUST001	+	−	−	101.74	94.48	70.47	63.70	48.84	19	103.92	103.29	102.75	56.25	12.42	68	−	+	−
HUST002	−	−	−	112.12	89.42	62.60	31.86	15.99	194	105.66	94.93	45.31	17.74	4.48	547	−	+	−
HUST003	+	+	+	106.71	97.45	67.50	44.38	19.33	120	109.97	109.29	90.54	54.56	−4.41	56	+	+	+
HUST004	+	+	+	105.40	88.68	73.52	62.87	56.94	3	109.18	107.70	103.23	87.50	62.08	10	+	+	+
HUST005	+	+	+	107.96	106.95	103.59	58.13	44.02	25	109.38	95.95	97.89	56.33	37.92	33	−	+	+
HUST006	−	−	−	78.54	17.16	5.59	−1.08	−10.50	5710	88.18	13.60	9.25	−2.98	−5.14	5745	−	−	−
HUST007	+	−	−	97.06	82.03	33.40	25.28	18.73	832	125.34	107.26	35.64	−3.78	−5.46	587	+	−	−
HUST008	−	−	−	99.71	81.92	42.76	30.32	11.34	399	105.41	103.72	27.53	8.78	−2.05	633	−	−	−
HUST009	−	−	−	94.51	84.24	26.54	16.43	8.34	870	121.62	104.90	18.83	−6.83	−17.04	688	+	+	−
HUST010	+	+	−	98.86	98.72	68.98	29.28	11.93	166	98.50	97.87	58.09	34.39	13.29	271	−	+	−
HUST011	+	+	−	98.10	54.71	47.71	39.48	24.42	695	85.25	47.37	27.53	13.06	−14.29	1721	+	+	−
HUST013	−	−	−	53.93	0.62	−3.91	−5.34	−6.81	9517	9.34	−3.28	−14.36	−19.50	−13.38	>10000	−	+	−
HUST014	+	−	−	91.67	80.05	52.38	43.63	11.27	249	109.90	106.17	86.86	46.85	−6.02	77	−	−	−
HUST015	−	−	−	99.05	83.68	70.60	37.20	15.59	129	101.49	97.87	76.25	32.02	−4.37	172	−	+	−
HUST017	−	−	−	22.66	−0.40	−1.00	−2.63	−8.75	>10000	−1.27	−1.70	−2.76	−1.54	−12.18	>10000	−	−	−
HUST018	+	+	−	42.02	6.29	4.41	−1.26	0.57	>10000	32.18	−0.88	−2.25	−12.44	−15.58	>10000	−	+	+
HUST026	+	+	+	92.08	86.55	37.72	28.64	22.61	623	104.63	86.23	38.05	21.95	10.72	691	−	+	−