| Gene (ORF number) | Protein name | Protein description | Immunoproteomic data | Seroreactivity at syphilis stages | Sensitivity/specificity; (% of positive result) | Links | Brinkman et al. [17] | McGill et al. [12] |
| Inner membrane lipoproteins | tp0171 | Tp15 | 15 kDa lipoprotein | None | +++ | All stages | 100/100 | [28] | tp0435 | Tp17 | 17 kDa lipoprotein | 9,6–16,6 | +++ | All stages | 96/100 | [28] | tp0574 | Tp47 | 47 kDa penicillin- binding protein, carboxypeptidase | 2,9–10,0 | +++ | All stages | 100/20 | [28] | tp0768 | TmpA | 44.5 kDa lipoprotein | 8,2–15,3 | +++ | All stages | 76–100/ 99,6 | [32] | tp0319 | TmpC | 35 kDa lipoprotein, purine nucleoside receptor A lipoprotein | 2,8–6,2 | +/++ | All stages | 100/100 | [34] | tp0684 | Tp38, MglB-2 | 38 kDa lipoprotein, methylgalactoside ABC transporter, galactose/glucose-binding lipoprotein | 6,8–19,0 | +++ | All stages | ND | [35] | tp0821 | Tp32 | 32 kDa lipoprotein, L-methionine-binding lipoprotein | 1,0–1,7 | None | All stages | 91,0–98,3/ 94,3–100 | [38] |
| Surface-exposed and outer membrane associated proteins | tp0897 | TprK | Heterogenic antigen variable by gene conversion | None | None | ND | ND | [43] [44] [45] | tp0663 | TROMP-2 | 28-kDa outer membrane protein, FlaA homolog | 0,8–1,9 | None | All stages | 98,83/100 | [47] | tp0326 | Tp92 | BamA (β-barrel assembly machinery protein A) ortholog | 1,2–2,6 | None | Mostly at primary stage; lower reactivity in secondary and early latent stage | 86/99 98/97 | [52] [55] | tp0453 | Tp0453 | Proposed carrier of lipids and glycolipids | None | +/++ | 98/100 100/100 | [52] [55] |
| Adhesins | tp0155 | Tp0155 | Binds to the matrix form of fibronectin and exhibit peptidase enzymatic activity | None | None | low reactive at primary stage | ND (27,9% positive) | [55] | tp0483 | Tp0483 | Binds to both the soluble and matrix forms of fibronectin | None | None | Low reactive at primary stage | ND (41,8% positive) | [55] | tp0136 | Tp0136 | 49 kDa outer membrane (lipo)protein; it binds to fibronectin and laminin | 0,7–2,1 | None | Primary stage | ND (85,5% positive) | [62] | tp0751 | Tp0751 | 25,8 kDa protein; it binds to laminin and exhibits metalloprotease activity | None | None | ND | ND (41,8% positive) | [55] | tp0750 | Tp0750 | Cotranscribed with Tp0751 serine protease | 0,8–2,1 | None | Primary and early latent stages | ND | [65] |
| Putative periplasmic proteins | tp0257 | Gpd | Glycerophosphodiester phosphodiesterase, binds Fc-fragment of human IgA, IgD, and IgG immunoglobulins | 3,0–7,3 | None | All stages | 91/93 | [55] | tp1038 | TpF1, 4D, C1–5 | bacterioferritin, homodecamer from 19-kDa subunits | 0,8–2,2 | +++ | All stages | 93–100/ 100 | [71] |
| Flagellar proteins | tp0868 | FlaB1 | Flagellar filament 34.5-kDa core protein | None | +++ | All stages | 95.4/98.9 | [73] | tp0792 | FlaB2 | Flagellar filament 33-kDa core protein | None | +++ | All stages | 92.6/95.8 | [73] | tp0870 | FlaB3 | Flagellar filament 31-kDa core protein | None | +++ | All stages | 95.1/95.8 | [73] |
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