Research Article

Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade

Table 2

Distribution of patient population in two groups. Group A: neutrophil-to-lymphocyte ratio (NLR) after 2 cycles ≤ median baseline NLR. Group B: NLR after 2 cycles > median baseline NLR. ECOG PS = Eastern Cooperative Oncology Group performance status; RMH = Royal Marsden Hospital; ANC = absolute neutrophil count; ALC = absolute lymphocyte count; SD = standard deviation; IQR = interquartile range; NLR = neutrophil-to-lymphocyte ratio.

CharacteristicGroup A ()Group B ()

Sex (%)
 Female11 (39)8 (30)
 Male17 (61)19 (70)
ECOG PS (%)
 016 (43)20 (74)
 112 (57)7 (26)
RMH prognostic score (%)
 0-125 (89)25 (93)
 2-33 (11)2 (7)
Intervention (%)
 Anti-PD-114 (50)8 (30)
 Anti-PD-L19 (32)17 (63)
 Anti-PD-1 plus TKI5 (18)2 (7)
Baseline ANC
Mean (SD)5.1 (1.8)4.1 (1.4)
Baseline ALC
Mean (SD)1.3 (0.6)1.3 (0.5)
Baseline NLR
Median (IQR)3.9 (2.7–5.6)3.0 (2.5–4.8)
ANC after 2 cycles
Median (IQR)3.7 (2.8–5.1)4.5 (3.5–5.7)
ALC after 2 cycles
Mean (SD)1.4 (0.5)1.2 (0.5)
NLR after 2 cycles
Median (IQR)2.9 (2.2–3.7)3.9 (2.8–7)