Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson’s Disease and Related Dementia

Table 6

Clinical characteristics of PD patients with and without dementia.

Variable (SD)	With dementia (17)	Without dementia (59)	value
Disease duration (year)	8.71 ± 6.06	5.10 ± 4.23	0.032
Age (year)	73.47 ± 7.89	68.10 ± 8.98	0.029
Onset age (year)	64.76 ± 12.18	63.00 ± 9.28	0.523
Gender, male	9 (52.9%)	36 (61.0%)	0.551
Albumin (g/L)	38.18 ± 3.91	39.22 ± 3.94	0.338
ALT (U/L)	15.63 ± 10.74	19.90 ± 14.18	0.267
AST (U/L)	23.69 ± 19.87	22.86 ± 11.55	0.832
TC (mmol/L)	4.05 ± 0.77	4.31 ± 0.85	0.272
TG (mmol/L)	1.13 ± 0.75	1.27 ± 0.76	0.502
Smoking history	4 (23.5%)	10 (16.9%)	0.794
Alcohol consumption	3 (17.6%)	4 (6.8%)	0.374
Hypertension	5 (29.4%)	24 (40.7%)	0.399
Diabetes mellitus	2 (11.8%)	8 (13.6%)	1.000
Hypercholesterolaemia	2 (11.8%)	13 (22.0%)	0.554
CHD	6 (35.3%)	9 (15.3%)	0.138
BMI	23.12 ± 3.13	23.33 ± 3.45	0.822
UPDRS score	76.06 ± 16.80	48.36 ± 23.10	<0.001
Advanced stage	15 (88.2%)	30 (50.8%)	0.006
BChE activity (IU/L)	5974.96 ± 1292.90	7127.81 ± 1253.21	0.003

PD, Parkinson’s disease; SD, standard deviation; ALT, alanine transaminase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; CHD, coronary heart disease; BMI, body mass index; UPDRS, unified Parkinson’s disease rating scale; BChE, butyrylcholinesterase.