Chlamydia muridarum Infection of Macrophages Stimulates IL-1β Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner

Figure 1

The activation of NLRP3 inflammasome induced by the LPS/ATP treatment. WT, Caspase-1^−/− BMDMs were stimulated by LPS/ATP and supernatants were analyzed for the secretion of IL-1β by ELISA (a). Western blot of both cell supernatants and lysates was performed for the detection of IL-1β (b) and Caspase-1 (c). The figure is shown by combining the values of three independent experiments; values = mean ± SE; .

(a)

(b)

(c)