BioMed Research International / 2017 / Article / Tab 2

Review Article

New Insights into the Epigenetics of Hepatocellular Carcinoma

Table 2

Role of different miRNAs in HCC.

miRNAFunction of miRNAGene target involvedReference

miRNA-221OncogenicDDIT4, CDKN1C/p57, CDKN1B/p27[39]
miRNA-125bTumor suppressorLIN28B[40]
miRNA-214Tumor suppressorc-Myc, TCF-1, Cyclin D1[41]
let-7 familyTumor suppressorc-Myc, STAT3[42]
miRNA-26Tumor suppressorMMP2, cyclin D1, Mcl-1, Bcl-2[43]
miRNA-122Tumor suppressorADAM10, igF1R, SRF, Cyclin G1, Wnt1, AKT3, Bcl-w[44, 45]
miRNA-96OncogenicephrinA5[46]
miRNA-101Tumor suppressorMcl-1[47]
miRNA-186Tumor suppressorYes-associated protein 1[48]
miRNA-29Tumor suppressorMcl-2, Bcl-2[49]
miRNA-125bTumor suppressorILL- 6R, Bcl-w, Mcl-1, Bcl-2[50]
miRNA-129-2Tumor suppressorHigh mobility group box 1[51]
miRNA-193a-3pOncogenicSRSF2[52]
miRNA-133bTumor suppressorSIRT1[53]
miRNA-199a-3pTumor suppressorc-Met, mTOR[54]
miRNA-199a-5pTumor suppressorATG7[55]
miRNA-155-3pOncogenicFBXW7[56]
miRNA-222OncogenicPPP2R2A, p27[57]
miRNA-21OncogenicPTEN, kinase 3[58]
miRNA-449aTumor suppressorADAM10[59]
miRNA-139Tumor suppressorROCK2, Rho Kinase 2[60]
miRNA-125bTumor suppressorLIN28B, PDZ binding motif, Sirtuin 7[40, 50, 60]
miRNA-182OncogenicephrinA5[46]
miRNA-125aTumor suppressorVEGF-A, MMP11[61]
miRNA-1180Increase apoptotic resistance to HCCThrough activation of NF-κB pathway[62]
miRNA-200 familyTumor suppressorZEB2, ZEB1[63]
miRNA-212Tumor suppressorFOXA1[64, 65]
miRNA-497Tumor suppressorYAP1[66]
miRNA-519dMetastasisPTEN[67]
miRNA-106bApoptosisBim[68]