New Insights into the Epigenetics of Hepatocellular Carcinoma

Table 4

Drugs that target epigenetic modifications in HCC [3].

Epigenetic modification	Drugs	Results	Ref.
Histone deacetylation that targets histone deacetylase	Suberoylanilide hydroxamic acid	TNF-related apoptosis-inducing ligand-induced apoptosis.	[100]
	Belinostat	Tumor stabilization was observed in nonresectable advanced HCC.	[101]
	Belinostat	Induction of apoptosis and inhibition of cell growth occurred.	[102]
DNA methylation that targets DNA methyltransferases	5-Aza-2′-deoxycytidine	Inhibition of telomerase activity and reactivation of c-Myc and p16 were observed.	[103]
	Zebularine	Induction of apoptosis and inhibition of cell proliferation were observed in HepG2 cell line.	[104]
	Zebularine	Tumor growth was inhibited in xenograft models. Genes involved in apoptosis, cell cycle, and tumor suppression were demethylated in KMHC and Huh-7 cell lines.	[105]
Combined epigenetic modifications that target tyrosine kinase inhibitors and histone deacetylase inhibitors	Panobinostat + sorafenib	Combined activity of these two drugs induced apoptosis, increased survival, and decreased tumor density and tumor volume.	[106]