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BioMed Research International
Volume 2017, Article ID 1634801, 7 pages
https://doi.org/10.1155/2017/1634801
Review Article

“mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

1Department of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, China
2Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China

Correspondence should be addressed to Xuehong Liu; moc.621@8856heuxuil

Received 5 December 2016; Revised 15 April 2017; Accepted 18 May 2017; Published 12 June 2017

Academic Editor: Ayhan Cömert

Copyright © 2017 Jingquan Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI. Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases. Previous research has already revealed that mTOR signaling pathway plays a vital role in prognosis, which involves the axon regeneration and autophagy. This review discusses a potential mechanism that curcumin suppresses the activation of this pathway and ameliorates the microenvironment of axons regeneration which would provide a new way that induces autophagy appropriately.