Phylogenetic Diversity in Core Region of Hepatitis C Virus Genotype 1a as a Factor Associated with Fibrosis Severity in HIV-1-Coinfected Patients

Figure 1

Graphical representation of HCV core nucleotide and amino acid sequences from 335 haplotypes. These were obtained from 18 HCV/HIV coinfected patients. The total height of each stack corresponds to a measure of the conservation of the column (the information content or entropy of that position expressed in bits). The relative height of each letter within a stack depends on the frequency of that letter at that position. Amino acid positions 70 and 91 are highlighted in bold.