Research Article

New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Table 1

Number of interactions between human and ZIKV proteins predicted by OralInt according the score (0.9–1: very high confidence; 0.7–0.9: high confidence; 0.7–0.4: medium confidence). Quantification refers to the number of human proteins which have been identified as being expressed upon ZIKV infection of fibroblast (skin) and human cortical neuronal progenitor cells (hNPCs).

Zika proteinOralInt score 0.9–1OralInt score 0.7–0.9OralInt score 0.4–0.7
PPIQuantified hNPCsPPIQuantified hNPCs + SkinPPIQuantified hNPCs + Skin

Capsid (C)--1686432361055 + 14 (4)
Envelope (E)7312442 + 12757838 + 11 (3)
Membrane (M)1-67151314369 + 3
NS13-11939 + 12612824 + 10 (3)
NS2A2126481 + 144781486 + 17 (6)
NS2B117439148 + 246491604 + 18 (4)
NS3113312 + 1979304 + 3 (1)
NS4A--12441 + 12618840 + 12 (3)
NS4B9-29283 + 138581189 + 12 (4)
NS55222978 + 139701330 + 17 (5)

Total39141859603 + 9304719869 + 103

[56]; [17].