New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Table 2

Number of human proteins establishing PPIs exclusively with each ZIKV protein; human proteins expression regulation upon ZIKV infection (when available) and respective presence in saliva. Only PPIs with scores ≥ 0.4 are shown.

Zika protein	Total PPIs	Human proteins with expression data		Proteins present in saliva
		Upregulated	Downregulated
E	105	16	21	8
M	62	8	9	3
NS1	131	16	14	4
NS2A	638	85	94	22
NS2B	1066	214	175	45
NS3	1	-	1	-
NS4A	46	5	7	3
NS4B	300	37	43	8
NS5	557	90	106	22

Quantification in human cortical neural progenitor cells (hNPCs) [56] and skin (fibroblasts) [17]. Presence in saliva from OralCard [57, 58].