New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Table 5

PPIs established between the nonstructural proteins of ZIKV and proteins of the host pathways leading to an antiviral state. Only proteins establishing PPIs with scores ≥ 0.2 are presented (OralInt prediction).

Pathway	Gene name	UniprotKB AC	PPI score with NS1	PPI score with NS2A	PPI score with NS2B	PPI score with NS3	PPI score with NS4A	PPI score with NS4B	PPI score with NS5	Fold change hNPCs	Fold change skin 6 h	Fold change skin 24 h
IFN receptor	IRF9	Q00978		0.2					0.2
	JAK1	P23458	0.2	0.3	0.4		0.3	0.4	0.3	1.3
	TYK2	P29597	0.3	0.3	0.3		0.2	0.3	0.2	1.5
Toll-like receptor	TNF	P01375		0.2							−1.7	−2.1
	IRAK1	P51617		0.2	0.2		0.2	0.2	0.2	−1.3	1.4	1.6
	IRAK2	O43187	0.3	0.3	0.3			0.3	0.2
	IRAK4	Q9NWZ3		0.2	0.2				0.2
	IKBKG (NEMO)	Q9Y6K9	0.3	0.2	0.2		0.2	0.3	0.2
	MYD88	Q99836	0.4	0.4	0.2		0.2	0.3	0.2	−1.8	−1.0	1.8
	NFKB	P19838	0.2	0.3	0.4	0.2	0.2	0.2	0.4	1.3	1.2	1.6
	TLR7	Q9NYK1									−1.7	−1.4
	TLR8	Q9NR97									−1.7	−1.4
	TLR9	Q9NR96									−1.0	−2.3
	TBK1	Q9UHD2		0.2	0.2					1.6	−1.2	1.1
RIG-like receptor	DDX3X (DDX3)	O00571			0.2						1.3	−1.1
	IKBKE (IKKε)	Q14164		0.3	0.4		0.2	0.2
	TRIM25	Q14258	0.4	0.6	0.4		0.3	0.4	0.4		1.4	1.8
	STAT1	P42224	0.8	0.5	0.7	0.7	0.6	0.6	0.8		1.1	1.8
	STAT2	P52630	0.3	0.3			0.2	0.3	0.2
	DDX58 (RIG-I)	O95786	0.2	0.2	0.2					2.0	−3.2	4.9
PKR-RNA and stress sensors (apoptosis modulation)	CASP8	Q14790									2.0	1.3
	CASP10	Q92851							0.2		3.3	3.3
	FADD	Q13158						0.2	0.1	1.5	−1.3	−1.1
	RIPK1 (RIP1)	Q13546	0.2	0.2	0.5		0.3	0.3	0.2		1.6	1.4
	TRADD	Q15628									1.5	1.3
Mitochondria antiviral immunity	IFNA1 (IFNα)	P01562					0.2	0.2			2.3	3.4
	IFNB1 (IFNβ)	P01574	0.3		0.2	0.3	0.2	0.3	0.4		−1.7	3.7
Toll/mitochondria antiviral immunity	TRAF6	Q9Y4K3	0.4	0.5	0.2	0.2	0.2	0.4	0.5	1.3	1.3	−1.1
	IFIH1 (MDA5)	Q9BYX4	0.4	0.5	0.4	0.4	0.4	0.3	0.6		−1.4	7.3
RIG/mitochondria antiviral immunity	IRF3	Q14653		0.3				0.2	0.2		−1.1	−1.1
	MAVS	Q7Z434								−1.3	−1.0	−1.5
Toll/RIG/mitochondria antiviral immunity	CHUK (IKKα)	O15111	0.3	0.3	0.4	0.2	0.4	0.2	0.3	1.3	1.0	1.2
	IKBKB (IKKβ)	O14920	0.2	0.4	0.6		0.4	0.2	0.2	−1.9	1.7	1.1
	IRF7	Q92985	0.2		0.2		0.2	0.2	0.3	1.6	1.3	3.2

Human cortical neural progenitor cells (hNPCs) [56]. Skin (fibroblasts) [17].