Pharmacokinetics of Quercetin-Loaded Methoxy Poly(ethylene glycol)-b-poly(L-lactic acid) Micelle after Oral Administration in Rats

Table 3

Pharmacokinetic parameters of QUT after single oral administration of QUT aqueous suspension or QUT-loaded MPEG-b-PLLA micelle, in rat .

Pharmacokinetic parameters	QUT aqueous suspension	QUT-loaded micelle
(h)	3.0 ± 1.1	7.3 ± 1.6^#
(h)	2.9 ± 0.6	12.7 ± 2.3^#
(h)	5.4 ± 0.5	20.2 ± 2.4^#
(ng/mL)	628.67 ± 64.66	1920.83 ± 250.14^#
(ng/mLh)	4318.42 ± 470.31	38312.97 ± 4346.72^#
(ng/mLh)	4633.71 ± 557.67	41677.10 ± 4573.95^#
CL (mL/h/kg)	36509 ± 6399	17730 ± 3387^#
(mL/kg)	8736 ± 1043	970 ± 115^#

, time to reach maximum concentration; , plasma half-life; MRT, mean residence time; , maximum drug concentration; AUC, area under curve; CL: plasma clearance; V: apparent volume of distribution. ^#Pharmacokinetic parameters obtained with QUT-loaded micelle were significantly different from QUT aqueous suspension at .