A Novel Phosphorylation Site-Kinase Network-Based Method for the Accurate Prediction of Kinase-Substrate Relationships

Figure 1

Construction of phosphorylation site-kinase network and extracting the pSKN profiles. The bipartite network represents the relationships between the phosphorylation sites and kinases; the orange and blue nodes represent phosphorylation sites and kinases, respectively. The matrix represents the pSKN profiles that are extracted from the bipartite network; each row is phosphorylation site and each column is kinase ; if is catalyzed by , the value is 1, otherwise 0.