Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis

Table 1

Characteristics of 11 articles included in our study that reported on using miR-375 as diagnostic biomarkers of various cancers.

Author/year	Country/ethnicity	Sample	Cancer type	change in cancer	Case/control	TP	FP	FN	TN	Quality score; (QUADAS)
Gao/2016	China/Asian	Plasma	Prostate cancer (versus benign prostate hyperplasia)	Up	57/28	43	7	14	21	8
Erbes et al./2015	Germany/Caucasian	Urine	Breast cancer	Down	24/24	16	5	8	19	8
Wach et al./2015	Germany/Caucasian	Serum	Prostate cancer (versus benign prostate hyperplasia)	Up	146/35	141	21	5	14	10
Roberts et al./2015	Australia/Caucasian	Ejaculate	Prostate cancer	Up	11/9	11	5	0	4	10
Kachakova et al./2015	Bulgaria/Caucasian	Serum	Prostate cancer (versus benign prostate hyperplasia)	Down	59/16	48	4	11	12	11
			Prostate cancer	Down	59/11	50	4	9	7	11
Yin et al./2015	China/Asian	Serum	Hepatocellular carcinoma	Down	78/156	41	43	37	113	11
Li et al./2015	China/Asian	Plasma	Esophageal squamous cell carcinoma	Up	38/19	28	1	10	18	11
Carlsen et al./2013	Denmark/Caucasian	Plasma	Pancreatic ductal adenocarcinoma	Up	47/45	36	16	11	29	10
Cheng et al./2013	America/Caucasian	Serum	Metastatic prostate cancer	Up	25/25	12	1	13	24	7
Haldrup et al./2013	Japan/Asian	Serum	Prostate cancer (versus benign prostate hyperplasia)	Up	31/13	7	0	24	13	10
Zhang et al./2012	China/Asian	Serum	Distal gastric adenocarcinoma	Down	20/20	17	4	3	16	11
Komatsu et al./2011	Japan/Asian	Plasma	Esophageal squamous cell carcinoma	Down	50/20	46	7	4	13	10

TP: true positives, FP: false positives, TN: true negatives, and FN: false negatives.