Healing and Antisecretory Effects of Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Unhealed Gastric Ulcers

Table 1

Effect of E. speciosa on “unhealed gastric ulcers” in pylorus-ligated rats.

Treatment	Dose (mg/kg)		Ulcerated area (mm^2)	% ulcerated area	% healing	Mucus production (mg)
Control 1	—	5	61.20 ± 3.61	9.07	—	78.68 ± 4.00
Control 2	—	5	39.20 ± 7.71	5.81	35.95	50.50 ± 1.47
E. speciosa	200	5	6.50 ± 0.39	0.96	83.42	80.25 ± 5.12
E. speciosa	400	5	4.50 ± 0.22	0.67	88.52	81.00 ± 3.42
Sucralfate	50	5	6.25 ± 0.80	0.93	84.06	76.50 ± 3.29

: number of rats. The values are expressed as mean ± SEM; ; ; statistically different compared to Control 2. Control 1: ulcerated rats sacrificed 4 days after acetic acid ulcer induction. Control 2: ulcerated rats given indomethacin alone for 14 days following ulcer induction.