Recent Progress in Deciphering the Etiopathogenesis of Primary Membranous Nephropathy
Table 3
Baseline characteristics and presence of PLA2R-Ab with respective associations and correlations with outcome and variables are highlighted. ß2m (ß2-microglobulin), eGFR (estimated glomerular filtration rate), PLA2R-Ab (phospholipase A2R-antibody). of different variables after adjustment of the respective antibody titers for fractional IgG excretion.
Antibody levels and proteinuria Antibody levels and serum creatinine () and eGFR Spontaneous remission more frequently in patients within the lowest PLA2R-Ab tertile () Highest tertile more often needed immunosuppression, and higher levels were associated with longer time to remission ()
Patients in the highest tertile were older (), had lower serum albumin (), and higher systolic blood pressure () Antibody level (IgG) is associated with outcome (serum creatinine increase ≥ 25% or creatinine level ≥ 1.3 mg/dl) Patients in tertile 3 reached the outcome parameters more frequently () and significantly faster Proteinuria was higher at the time of last follow-up in patients within tertile 3 ()
PLA2R-Ab levels correlated with proteinuria and serum creatinine Lower PLA2R-Ab titers were associated with a faster time to remission and remission was achieved more frequently
PLA2R-Ab positivity was associated with treatment resistance () Higher levels were associated with resistant disease (55%); low titers were associated with remission (68%)
PLA2R-Ab positivity was associated with a higher level of proteinuria () and a lower level of eGFR () Antibody levels correlated with proteinuria (), serum albumin (), and eGFR () Patients with glomerular positivity (undetectable antibodies) were more likely to achieve complete remission ()
PLA2R-Ab positivity was associated with lower serum albumin () and higher levels of proteinuria () and nephrotic range proteinuria was more frequently observed ()