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BioMed Research International
Volume 2017 (2017), Article ID 1948985, 11 pages
https://doi.org/10.1155/2017/1948985
Research Article

Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis

1Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

Correspondence should be addressed to Ying Peng

Huan Liao and Hongxuan Wang contributed equally to this work.

Received 19 July 2017; Accepted 8 November 2017; Published 7 December 2017

Academic Editor: Nobuo Kanazawa

Copyright © 2017 Huan Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. P. Mehta and M. S. Ahluwalia, “Whole-brain radiotherapy and stereotactic radiosurgery in brain metastases: what is the evidence?” American Society of Clinical Oncology Educational Book, pp. e99–e104, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. T. B. Johannesen, F. Langmark, and K. Lote, “Cause of death and long-term survival in patients with neuro-epithelial brain tumours: a population-based study,” European Journal of Cancer, vol. 39, no. 16, pp. 2355–2363, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. M. Cole, A. Scherwath, G. Ernst, H. Lanfermann, M. Bremer, and D. Steinmann, “Self-reported cognitive outcomes in patients with brain metastases before and after radiation therapy,” International Journal of Radiation Oncology • Biology • Physics, vol. 87, no. 4, pp. 705–712, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Beltran, M. Naik, and T. E. Merchant, “Dosimetric effect of target expansion and setup uncertainty during radiation therapy in pediatric craniopharyngioma,” Radiotherapy & Oncology, vol. 97, no. 3, pp. 399–403, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Li, S. M. Bentzen, J. Li, M. Renschler, and M. P. Mehta, “Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis,” International Journal of Radiation Oncology • Biology • Physics, vol. 71, no. 1, pp. 64–70, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Welzel, K. Fleckenstein, S. K. Mai, B. Hermann, U. Kraus-Tiefenbacher, and F. Wenz, “Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors,” Strahlentherapie und Onkologie, vol. 184, no. 12, pp. 647–654, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Welzel, K. Fleckenstein, J. Schaefer et al., “Memory function before and after whole brain radiotherapy in patients with and without brain metastases,” International Journal of Radiation Oncology • Biology • Physics, vol. 72, no. 5, pp. 1311–1318, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Qing and X. Ma, “Application of 256-slice computed tomography with low radiation doses in neonates with hypoxic-ischemic encephalopathy,” Experimental and Therapeutic Medicine, vol. 6, no. 6, pp. 1414–1416, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. B. Oh, H. R. Park, Y. J. Jang, S. Y. Choi, T. G. Son, and J. Lee, “Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation,” British Journal of Pharmacology, vol. 168, no. 2, pp. 421–431, 2013. View at Publisher · View at Google Scholar
  10. D. M. Greene-Schloesser, E. Moore, and M. E. Robbins, “Molecular pathways: radiation-induced cognitive impairment,” Clinical Cancer Research, vol. 19, no. 9, pp. 2294–2300, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Kamiryo, M. B. S. Lopes, N. F. Kassell, L. Steiner, and K. S. Lee, “Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil,” Neurosurgery, vol. 49, no. 2, pp. 409–415, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Ye, X. Rong, Y. Xiang, Y. Xing, and Y. Tang, “A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis,” PLoS ONE, vol. 7, no. 8, Article ID e42890, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. C. I. Schnegg, M. Kooshki, F.-C. Hsu, G. Sui, and M. E. Robbins, “PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway,” Free Radical Biology & Medicine, vol. 52, no. 9, pp. 1734–1743, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. L. G. Caceres, L. Aon Bertolino, G. E. Saraceno et al., “Hippocampal-related memory deficits and histological damage induced by neonatal ionizing radiation exposure. Role of oxidative status.,” Brain Research, vol. 1312, pp. 67–78, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. E. A. Miao, J. V. Rajan, and A. Aderem, “Caspase-1-induced pyroptotic cell death,” Immunological Reviews, vol. 243, no. 1, pp. 206–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Linkermann, B. R. Stockwell, S. Krautwald, and H.-J. Anders, “Regulated cell death and inflammation: an auto-amplification loop causes organ failure,” Nature Reviews Immunology, vol. 14, no. 11, pp. 759–767, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Shi, Y. Zhao, K. Wang et al., “Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death,” Nature, vol. 526, no. 7575, pp. 660–665, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Schroder and J. Tschopp, “The inflammasomes,” Cell, vol. 140, no. 6, pp. 821–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Ortiz, D. Acuña-Castroviejo, C. Doerrier et al., “Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis,” Journal of Pineal Research, vol. 58, no. 1, pp. 34–49, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. S.-H. Sohn, J. M. Lee, S. Park et al., “The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice,” Environmental Toxicology and Pharmacology, vol. 39, no. 2, pp. 917–926, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Naji, N. Rouas-Freiss, A. Durrbach, E. D. Carosella, L. Sensebe, and F. Deschaseaux, “Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy,” Stem Cells, vol. 31, no. 11, pp. 2296–2303, 2013. View at Publisher · View at Google Scholar
  22. D. J. Weiss, “Concise review: current status of stem cells and regenerative medicine in lung biology and diseases,” Stem Cells, vol. 32, no. 1, pp. 16–25, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. M. M. Acharya, L.-A. Christie, M. L. Lan, and C. L. Limoli, “Comparing the functional consequences of human stem cell transplantation in the irradiated rat brain,” Cell Transplantation, vol. 22, no. 1, pp. 55–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. M. M. Acharya, L.-A. Christie, T. G. Hazel, K. K. Johe, and C. L. Limoli, “Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation,” Cell Transplantation, vol. 23, no. 10, pp. 1255–1266, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Q. Zhu, X.-X. Li, W. Wang et al., “Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats,” American Journal of Physiology-Renal Physiology, vol. 310, no. 7, pp. F621–F627, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. S.-Y. Hwang, J.-S. Jung, T.-H. Kim et al., “Ionizing radiation induces astrocyte gliosis through microglia activation,” Neurobiology of Disease, vol. 21, no. 3, pp. 457–467, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Naji, B. A. Muzembo, K.-I. Yagyu et al., “Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells,” Scientific Reports, vol. 6, Article ID 26162, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. M. M. Acharya, L.-A. Christie, M. L. Lan et al., “Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 106, no. 45, pp. 19150–19155, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. E. Baulch, M. M. Acharya, B. D. Allen et al., “Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 113, no. 17, pp. 4836–4841, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. P. R. Krafft, O. Altay, W. B. Rolland et al., “α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage,” Stroke, vol. 43, no. 3, pp. 844–850, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Chen, Y. Lu, Z. Cao et al., “Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells,” Toxicology Letters, vol. 246, pp. 7–16, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. U. Raju, G. J. Gumin, and P. J. Tofilon, “Radiation-induced transcription factor activation in the rat cerebral cortex,” International Journal of Radiation Biology, vol. 76, no. 8, pp. 1045–1053, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Zhang, Z. Cheng, C. Wang, H. Ma, W. Meng, and Q. Zhao, “Neuroprotective effects of Kukoamine a against radiation-induced rat brain injury through inhibition of oxidative stress and neuronal apoptosis,” Neurochemical Research, vol. 41, no. 10, pp. 2549–2558, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. V. M. Stoecklein, A. Osuka, S. Ishikawa, M. R. Lederer, L. Wanke-Jellinek, and J. A. Lederer, “Radiation exposure induces inflammasome pathway activation in immune cells,” The Journal of Immunology, vol. 194, no. 3, pp. 1178–1189, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. S. M. Srinivasula, J.-L. Poyet, M. Razmara, P. Datta, Z. Zhang, and E. S. Alnemri, “The PYRIN-CARD protein ASC is an activating adaptor for caspase-1,” The Journal of Biological Chemistry, vol. 277, no. 24, pp. 21119–21122, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Genc, E. Genc, B. O. Genc, and D. A. Kiresi, “Significant response of radiation induced CNS toxicity to high dose steroid administration,” British Journal of Radiology, vol. 79, no. 948, pp. e196–e199, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Wang, C. Ting, M. Yen et al., “Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials,” Journal of Biomedical Science, vol. 23, no. 76, 2016. View at Publisher · View at Google Scholar
  38. Y. C.-Y. Hsuan, C.-H. Lin, C.-P. Chang, and M.-T. Lin, “Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke,” Brain and Behavior, vol. 6, Article ID e00526, 2016. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Kim, J. Kim, and J.-S. Bae, “ROS homeostasis and metabolism: a critical liaison for cancer therapy,” Experimental & Molecular Medicine, vol. 48, no. 11, article no. e269, 2016. View at Publisher · View at Google Scholar · View at Scopus