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BioMed Research International
Volume 2017, Article ID 1972608, 11 pages
https://doi.org/10.1155/2017/1972608
Research Article

The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model

1Department of Neurobiology, Jinzhou Medical University, Jinzhou, Liaoning Province 121000, China
2Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province 121000, China
3Department of Immunology, Jinzhou Medical University, Jinzhou, Liaoning Province 121000, China
4Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province 121000, China

Correspondence should be addressed to Chang Liu; moc.kooltuo@iemxuilc and Xifan Mei; moc.kooltuo@iemfx

Received 22 January 2017; Revised 6 April 2017; Accepted 13 April 2017; Published 5 July 2017

Academic Editor: John H. Zhang

Copyright © 2017 Donghe Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Penas, M.-S. Guzmán, E. Verdú, J. Forés, X. Navarro, and C. Casas, “Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response,” Journal of Neurochemistry, vol. 102, no. 4, pp. 1242–1255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. J. Moon, J. Y. Lee, M. S. Oh et al., “Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury,” Journal of Neuroscience Research, vol. 90, no. 1, pp. 243–256, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Zhou, P. Lu, H. Ren et al., “17β-estradiol protects human eyelid-derived adipose stem cells against cytotoxicity and increases transplanted cell survival in spinal cord injury,” Journal of Cellular and Molecular Medicine, vol. 18, no. 2, pp. 326–343, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Gu, H. Li, C. Wang et al., “Bone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury,” Neuroscience Letters, vol. 636, pp. 282–289, 2017. View at Publisher · View at Google Scholar
  5. J. F. Bonner and O. Steward, “Repair of spinal cord injury with neuronal relays: from fetal grafts to neural stem cells,” Brain Research, vol. 1619, pp. 115–123, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Usas, J. Maciulaitis, R. Maciulaitis, N. Jakuboniene, A. Milasius, and J. Huard, “Skeletal muscle-derived stem cells: implications for cell-mediated therapies,” Medicina (Kaunas), vol. 47, pp. 469–479, 2011. View at Google Scholar
  7. J. S. Oh, K. N. Kim, S. S. An et al., “Cotransplantation of mouse neural stem cells (mNSCs) with adipose tissue-derived mesenchymal stem cells improves mNSC survival in a rat spinal cord injury model,” Cell Transplantation, vol. 20, no. 6, pp. 837–849, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. B. Jazayeri, S. Beygi, F. Shokraneh, E. M. Hagen, and V. Rahimi-Movaghar, “Incidence of traumatic spinal cord injury worldwide: a systematic review,” European Spine Journal, vol. 24, no. 5, pp. 905–918, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. T. J. Burkholder, B. Fingado, S. Baron, and R. L. Lieber, “Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb,” Journal of Morphology, vol. 221, no. 2, pp. 177–190, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Y. Lee, Z. Qu-Petersen, B. Cao et al., “Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing,” Journal of Cell Biology, vol. 150, no. 5, pp. 1085–1100, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Danisovic, I. Varga, S. Polak, M. Ulicna, D. Bohmer, and J. Vojtassak, “Morphology of in vitro expanded human muscle-derived stem cells,” Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic, vol. 152, no. 2, pp. 235–238, 2008. View at Publisher · View at Google Scholar
  12. J. Tsao, D. A. Vernet, R. Gelfand et al., “Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle,” Stem Cell Research and Therapy, vol. 4, no. 1, article 4, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Mateos, A. De la Fuente, I. Lesende-Rodriguez, P. Fernández-Pernas, M. C. Arufe, and F. J. Blanco, “Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress,” Stem Cell Research, vol. 11, no. 3, pp. 1137–1148, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. X.-F. Huang, S.-K. Luo, J. Xu et al., “Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia,” Blood, vol. 111, no. 5, pp. 2854–2865, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. J. W. Kaspar, S. K. Niture, and A. K. Jaiswal, “Nrf2:INrf2 (Keap1) signaling in oxidative stress,” Free Radical Biology and Medicine, vol. 47, no. 9, pp. 1304–1309, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Zhai, S. E. Gomez-Mejiba, M. S. Gimenez et al., “Free radical-operated proteotoxic stress in macrophages primed with lipopolysaccharide,” Free Radical Biology and Medicine, vol. 53, no. 1, pp. 172–181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Zhang, P. Tang, H. Hou et al., “Autophagy reduces neuronal damage and promotes locomotor recovery via inhibition of apoptosis after spinal cord injury in rats,” Molecular Neurobiology, vol. 49, no. 1, pp. 276–287, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Zhang, B. Tang, X. Xie, Y.-F. Xiao, S.-M. Yang, and J.-W. Zhang, “The interplay between DNA repair and autophagy in cancer therapy,” Cancer Biology and Therapy, vol. 16, no. 7, pp. 1005–1013, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Hara, K. Nakamura, M. Matsui et al., “Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice,” Nature, vol. 441, no. 7095, pp. 885–889, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Yu, L. Li, R. Liu et al., “Autophagy in long propriospinal neurons is activated after spinal cord injury in adult rats,” Neuroscience Letters, vol. 634, pp. 138–145, 2016. View at Publisher · View at Google Scholar
  21. M. Sasaki, C. Radtke, A. M. Tan et al., “BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury,” The Journal of Neuroscience, vol. 29, no. 47, pp. 14932–14941, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Chen, H.-C. Park, F. Addabbo et al., “Kidney-derived mesenchymal stem cells contribute to vasculogenesis, angiogenesis and endothelial repair,” Kidney International, vol. 74, no. 7, pp. 879–889, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. L. B. Balsam, A. J. Wagers, J. L. Christensen, T. Kofidis, I. L. Weissmann, and R. C. Robbins, “Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium,” Nature, vol. 428, no. 6983, pp. 668–673, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Anthony Altar, N. Cai, T. Bliven et al., “Anterograde transport of brain-derived neurotrophic factor and its role in the brain,” Nature, vol. 389, no. 6653, pp. 856–860, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Hwang, I.-Y. Choi, S.-E. Kim et al., “Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus,” International Journal of Molecular Medicine, vol. 31, no. 5, pp. 1047–1056, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. W.-R. Schabitz, C. Sommer, W. Zoder et al., “Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia,” Stroke, vol. 31, no. 9, pp. 2212–2217, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. J. S. Allard, E. J. Perez, K. Fukui, P. Carpenter, D. K. Ingram, and R. D. Cabo, “Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice,” Behavioural Brain Research, vol. 301, pp. 1–9, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Gao, G. Wang, Y. Wang et al., “Neuroprotective effect of simvastatin via inducing the autophagy on spinal cord injury in the rat model,” BioMed Research International, vol. 2015, Article ID 260161, 9 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Zhang, J. Li, R. Lea, K. Vleminckx, and E. Amaya, “Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development,” Development, vol. 141, no. 24, pp. 4794–4805, 2014. View at Publisher · View at Google Scholar
  30. L. Sun, J. Pan, Y. Peng et al., “Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling,” Journal of Spinal Cord Medicine, vol. 36, no. 6, pp. 616–622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. G. S. Miranpuri, D. T. Schomberg, B. Alrfaei et al., “Role of matrix metalloproteinases 2 in spinal cord injury-induced neuropathic pain,” Annals of Neurosciences, vol. 23, no. 1, pp. 25–32, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Zhang, G. Feng, G. Bao et al., “Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and β-catenin pathway after spinal cord injury,” Cell Cycle, vol. 14, no. 16, pp. 2609–2618, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. L. F. Leal, A. C. Bueno, D. C. Gomes, R. Abduch, M. de Castro, and S. R. Antonini, “Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis,” Oncotarget, vol. 6, no. 40, pp. 43016–43032, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Z. Xu, D. F. Xu, Y. Han et al., “BDNF-GSK-3beta-beta-catenin pathway in the mPFC is involved in antidepressant-like effects of morinda officinalis oligosaccharides in rats,” International Journal of Neuropsychopharmacology, vol. 20, no. 1, pp. 83–93, 2017. View at Google Scholar
  35. C. Clow and B. J. Jasmin, “Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration,” Molecular Biology of the Cell, vol. 21, no. 13, pp. 2182–2190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. N. D. Leipzig, C. Xu, T. Zahir, and M. S. Shoichet, “Functional immobilization of interferon-gamma induces neuronal differentiation of neural stem cells,” Journal of Biomedical Materials Research—Part A, vol. 93, no. 2, pp. 625–633, 2010. View at Publisher · View at Google Scholar · View at Scopus