Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 2032697, 12 pages
https://doi.org/10.1155/2017/2032697
Research Article

Protective Effects of Genistein against Mono-(2-ethylhexyl) Phthalate-Induced Oxidative Damage in Prepubertal Sertoli Cells

1Department of Urology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China
2Department of Nephrology, Xi’an No. 4 Hospital, Xi’an, Shaanxi 710004, China

Correspondence should be addressed to Ziming Wang; ten.362@w-gnimiz

Received 2 May 2017; Revised 13 August 2017; Accepted 21 August 2017; Published 13 November 2017

Academic Editor: Ferdinando Chiaradonna

Copyright © 2017 Liandong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Nassouri, F. Archambeaud, and R. Desailloud, “Endocrine disruptors: echoes of congress of Endocrinology in 2012,” Annales d'Endocrinologie, vol. 73, supplement 1, pp. S36–S44, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Chen, K. S. Saili, Y. Liu et al., “Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish,” Chemosphere, vol. 169, pp. 262–270, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. X.-Z. Wang, S.-S. Liu, Y. Sun, J.-Y. Wu, Y.-L. Zhou, and J.-H. Zhang, “Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress,” Theriogenology, vol. 72, no. 5, pp. 599–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Sidorkiewicz, K. Zaręba, S. Wołczyński, and J. Czerniecki, “Endocrine-disrupting chemicals—Mechanisms of action on male reproductive system,” Toxicology & Industrial Health, vol. 33, no. 7, pp. 601–609, 2017. View at Publisher · View at Google Scholar
  5. C. R. Cederroth, J. Auger, C. Zimmermann, F. Eustache, and S. Nef, “Soy, phyto-oestrogens and male reproductive function: a review,” International Journal of Andrology, vol. 33, no. 2, pp. 304–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Zhao, Y. Wang, J. Liu et al., “Protective effects of genistein and puerarin against chronic alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms,” Journal of Agricultural and Food Chemistry, vol. 64, no. 38, pp. 7291–7297, 2016. View at Publisher · View at Google Scholar
  7. J. Kumi-Diaka, V. Nguyen, and A. Butler, “Cytotoxic potential of the phytochemical genistein isoflavone (4',5',7-trihydroxyisoflavone) and certain environmental chemical compounds on testicular cells,” Biology of the Cell, vol. 91, no. 7, pp. 515–523, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. D. K. Gong, B. H. Liu, and X. H. Tan, “Genistein prevents cadmium-induced neurotoxic effects through its antioxidant mechanisms,” Drug Research, 2014. View at Publisher · View at Google Scholar
  9. S. R. Georgetti, R. Casagrande, F. T. M. C. Vicentini, M. M. Baracat, W. A. Verri Jr., and M. J. V. Fonseca, “Protective effect of fermented soybean dried extracts against TPA-induced oxidative stress in hairless mice skin,” BioMed Research International, vol. 2013, Article ID 340626, 8 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Culty, R. Thuillier, W. Li et al., “In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat,” Biology of Reproduction, vol. 78, no. 6, pp. 1018–1028, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. C. M. Sobarzo, N. D. M. Rosana, L. Livia, D. Berta, and H. F. Schteingart, “Mono-(2-ethylhexyl) phthalate (MEHP) affects intercellular junctions of Sertoli cell: A potential role of oxidative stress,” Reproductive Toxicology, vol. 58, pp. 203–212, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Kim, S. Kang, G. Lee et al., “Urinary phthalate metabolites among elementary school children of Korea: sources, risks, and their association with oxidative stress marker,” Science of the Total Environment, vol. 472, pp. 49–55, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Jones, A. Boisvert, S. Francois, L. Zhang, and M. Culty, “In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment,” Biology of Reproduction, vol. 93, no. 4, article no. 92, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. R. P. Grinspon and R. A. Rey, “Anti-müllerian hormone and sertoli cell function in paediatric male hypogonadism,” Hormone Research in Paediatrics, vol. 73, no. 2, pp. 81–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Silins and J. Högberg, “Combined toxic exposures and human health: biomarkers of exposure and effect,” International Journal of Environmental Research and Public Health, vol. 8, no. 3, pp. 629–647, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Wang, M. Xu, and S. Zhang, “The modified isolation and culture method of rat Sertoli cells,” Sichuan Da Xue Xue Bao Yi Xue Ban, vol. 34, no. 4, pp. 736-737, 2003. View at Google Scholar
  17. V. Muczynski, J. P. Cravedi, A. Lehraiki et al., “Effect of mono-(2-ethylhexyl) phthalate on human and mouse fetal testis: In vitro and in vivo approaches,” Toxicology and Applied Pharmacology, vol. 261, no. 1, pp. 97–104, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Cao, A. M. Calafat, D. R. Doerge et al., “Isoflavones in urine, saliva, and blood of infants: Data from a pilot study on the estrogenic activity of soy formula,” Journal of Exposure Science and Environmental Epidemiology, vol. 19, no. 2, pp. 223–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. E. Perobelli, “The male peripubertal phase as a developmental window for reproductive toxicology studies,” Current Pharmaceutical Design, vol. 20, no. 34, pp. 5398–5415, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. N. E. Skakkebaek, E. Rajpert-De Meyts, G. M. Buck Louis et al., “Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility,” Physiological Reviews, vol. 96, no. 1, pp. 55–97, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Schlatt and J. Ehmcke, “Regulation of spermatogenesis: an evolutionary biologist's perspective,” Seminars in Cell & Developmental Biology, vol. 29, no. 1, pp. 2–16, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Johnson, D. L. Thompson Jr., and D. D. Varner, “Role of Sertoli cell number and function on regulation of spermatogenesis,” Animal Reproduction Science, vol. 105, no. 1-2, pp. 23–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C. J. Murphy, A. R. Stermer, and J. H. Richburg, “Age- and species-dependent infiltration of macrophages into the testis of rats and mice exposed to mono-(2-ethylhexyl) phthalate (MEHP),” Biology of Reproduction, vol. 91, no. 1, article no. 18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Kleymenova, C. Swanson, K. Boekelheide, and K. W. Gaido, “Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat sertoli cells and disrupts sertoli cell-gonocyte contact,” Biology of Reproduction, vol. 73, no. 3, pp. 482–490, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Chauvigné, A. Menuet, L. Lesné et al., “Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat retal testis in vitro,” Environmental Health Perspectives, vol. 117, no. 4, pp. 515–521, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Lehraiki, C. Racine, A. Krust, R. Habert, and C. Levacher, “Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism,” Toxicological Sciences, vol. 111, no. 2, pp. 372–382, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. B.-G. Xie, J. Li, and W.-J. Zhu, “Pathological changes of testicular tissue in normal adult mice: A retrospective analysis,” Experimental and Therapeutic Medicine, vol. 7, no. 3, pp. 654–656, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-J. Wu, C. Liu, W.-X. Duan et al., “Melatonin ameliorates bisphenol A-induced DNA damage in the germ cells of adult male rats,” Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 752, no. 1-2, pp. 57–67, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Jones, A. Boisvert, and TB. Duong, “Disruption of Rat Testis Development Following Combined In,” BIOL REPROD, 2014. View at Google Scholar
  30. L.-D. Zhang, Q. Deng, Z.-M. Wang et al., “Disruption of reproductive development in male rat offspring following gestational and lactational exposure to di-(2-ethylhexyl) phthalate and genistein,” Biological Research, vol. 46, no. 2, pp. 139–146, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Erkekoglu, W. Rachidi, O. G. Yuzugullu et al., “Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium,” Toxicol Appl Pharmacol, vol. 248, no. 1, pp. 52–62, 2010. View at Google Scholar
  32. E. Kasahara, E. F. Sato, M. Miyoshi et al., “Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate,” Biochemical Journal, vol. 365, no. 3, pp. 849–856, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Hsu, Y. Kuo, Y. Leon Guo et al., “The adverse effects of low-dose exposure to Di(2-ethylhexyl) phthalate during adolescence on sperm function in adult rats,” Environmental Toxicology, vol. 31, no. 6, pp. 706–712, 2016. View at Publisher · View at Google Scholar
  34. Y. Qian, T. Guan, M. Huang et al., “Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model,” Neurochemistry International, vol. 60, no. 8, pp. 759–767, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. M. H. Javanbakht, R. Sadria, and M. Djalali, “Soy protein and genistein improves renal antioxidant status in experimental nephrotic syndrome,” Nefrología, vol. 34, no. 4, pp. 483–490, 2014. View at Publisher · View at Google Scholar
  36. W. Y. Boadi and D. Johnson, “Effects of low doses of quercetin and genistein on oxidation and carbonylation in hemoglobin and myoglobin,” Journal of Dietary Supplements, vol. 11, no. 3, pp. 272–287, 2014. View at Publisher · View at Google Scholar
  37. W. Banz, S. Hauck, B. Gename, T. Winters, and A. Bartke, “Soy isoflavones modify liver free radical scavenger systems and liver parameters in Sprague-Dawley rats,” Journal of Medicinal Food, vol. 7, no. 4, pp. 477–481, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. M. C. Lu, J. A. Ji, Z. Y. Jiang, and Q. D. You, “The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update,” Medicinal Research Reviews, vol. 36, no. 5, pp. 924–963, 2016. View at Publisher · View at Google Scholar
  39. M. D. Maines and J. F. Ewing, “Stress response of the rat testis: In situ hybridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia,” Biology of Reproduction, vol. 54, no. 5, pp. 1070–1079, 1996. View at Publisher · View at Google Scholar · View at Scopus