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BioMed Research International
Volume 2017, Article ID 2059825, 7 pages
https://doi.org/10.1155/2017/2059825
Research Article

Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™

1Department of Acute Medicine, Oslo University Hospital, Ullevål, Kirkeveien 166, 0407 Oslo, Norway
2Institute of Clinical Medicine, University of Oslo, P.O. Box 1171, 0318 Oslo, Norway
3Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), St. Olav’s University Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, Norway
4Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevål, Kirkeveien 166, 0407 Oslo, Norway

Correspondence should be addressed to Jon-Magnus Tangen; moc.oohay@negnatmj

Received 13 July 2017; Revised 3 October 2017; Accepted 10 October 2017; Published 7 November 2017

Academic Editor: Francesco Di Raimondo

Copyright © 2017 Jon-Magnus Tangen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4% Agaricus blazei Murill, together with medicinal mushrooms Hericium erinaceus (14.7%) and Grifola frondosa (2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell lines in vitro. Although the exact content and hence the mechanisms of action of the Andosan extract are unknown, we have found in this investigation indications of cell cycle arrest when myeloma cell lines are cultivated with Andosan. This may be one of the possible explanations for the cytotoxic effects of Andosan.