Research Article

Protection against Blast-Induced Traumatic Brain Injury by Increase in Brain Volume

Figure 5

(a) Microphotographs of ETRA immunoreactivity in frontal cortex. Scale bars: 100 μm (A) and 50 μm (B). (b) Quantitative analysis of fluorescence density of ETRA in cortex. The density of fluorescence is significantly increased in cortex of rats after blast. IJV compression did not significantly change the blast-induced increase in ETRA. Con, nonexposed control; Blast, animals exposed to blast; and I-Blast, animals with IJV compression exposed to BOP. , control versus Blast (). (c) Microphotographs of ETRA immunoreactivity in hippocampus. Scale bars: 100 μm (A) and 50 μm (B). (d) Quantitative analysis of fluorescence density of ETRA in hippocampus. The density of ETRA fluorescence was significantly increased after blast and remained elevated after IJV compression, ~25% over controls. compared with control (/group). Note that -axes in (c) and (d) do not cross -axis at zero density.
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